Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7791316 | 0.88 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1MITFNPC1 | |
| SCHEMBL7723906 | 0.86 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTALDH1A1NPC1KMT2A | |
| SCHEMBL550516 | 0.85 | SMN1; SMN2 (0.63) | SMN1; SMN2MAPTALDH1A1NPC1KMT2A | |
| SCHEMBL14114749 | 0.84 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTALDH1A1MITFNPC1 | |
| SCHEMBL2616927 | 0.84 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTALDH1A1NPC1KMT2A | |
| SCHEMBL3299225 | 0.84 | CA12 (0.62) | SMN1; SMN2MAPTALDH1A1NPC1KMT2A | |
| SCHEMBL7665374 | 0.84 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTALDH1A1MITFNPC1 | |
| SCHEMBL527397 | 0.83 | ALDH1A1 (0.52) | MAPTALDH1A1NPC1KMT2AMEN1 | |
| SCHEMBL550921 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTALDH1A1MITFNPC1 | |
| SCHEMBL4420346 | 0.82 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTALDH1A1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014167444-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2014-10-16 | — | — | WO | disclosed |
| WO-2014167444-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2014-10-16 | — | — | WO | disclosed |
| US-6251917-B1 | Benzamidoaldehydes and their use as cysteine protease inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 2001-06-26 | — | — | US | disclosed |
| US-5994544-A | PRODUCING A 5H-CHROMENO(3,4-F)QUINOLINE | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1999-11-30 | — | — | US | disclosed |