Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.68 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.65 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 2/20 | 0.51 |
| ▸ | PRKX | P51817 | 2/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26668737 | 1.00 | CHRNB2 (0.68) | CHRNB2CHRNA4ROCK1PRKCZROCK2 | |
| SCHEMBL26668743 | 1.00 | CHRNB2 (0.68) | CHRNB2CHRNA4ROCK1PRKCZROCK2 | |
| Hydrochloric Acid SCHEMBL26599814 | 0.98 | CHRNB2 (0.66) | CHRNB2CHRNA4ROCK1PRKCZROCK2 | |
| Hydrochloric Acid SCHEMBL15650400 | 0.98 | CHRNB2 (0.66) | CHRNB2CHRNA4ROCK1PRKCZROCK2 | |
| Hydrochloric Acid SCHEMBL26599582 | 0.98 | CHRNB2 (0.66) | CHRNB2CHRNA4ROCK1PRKCZROCK2 | |
| Hydrochloric Acid SCHEMBL26599588 | 0.98 | CHRNB2 (0.66) | CHRNB2CHRNA4ROCK1PRKCZROCK2 | |
| SCHEMBL2264511 | 0.89 | CHRNB2 (0.66) | CHRNB2CHRNA4ROCK1PRKCZROCK2 | |
| SCHEMBL2266554 | 0.89 | CHRNB2 (0.66) | CHRNB2CHRNA4ROCK1PRKCZROCK2 | |
| SCHEMBL2110195 | 0.89 | CHRNB2 (0.66) | CHRNB2CHRNA4ROCK1PRKCZROCK2 | |
| SCHEMBL17593357 | 0.82 | CHRNB2 (0.67) | CHRNB2CHRNA4ROCK1ROCK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909170-A1 | SUBSTITUTED CARBAMATE COMPOUNDS AND THEIR USE AS TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2015-08-26 | — | — | EP | disclosed |
| WO-2014060341-A1 | SUBSTITUTED CARBAMATE COMPOUNDS AND THEIR USE AS TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-24 | — | — | WO | disclosed |
| US-20010014691-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | TARGACEPT, INC. | 2001-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010014691-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | PNMT, HNMT, CHRM3 | CHRNB2 32/4885CHRNA4 34/4885ROCK1 4518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.