Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ATF4 | P18848 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | RHOC | P08134 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668906 | 0.82 | POLB (0.68) | POLBALDH1A1EPHX1NPC1CYP2C9 | |
| SCHEMBL11808670 | 0.82 | POLB (0.68) | POLBALDH1A1EPHX1NPC1CYP2C9 | |
| SCHEMBL25039445 | 0.81 | EPHX2 (0.55) | EPHX1NPC1RAB9ASMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL1919158 | 0.80 | POLB (0.66) | POLBALDH1A1EPHX1NPC1CYP2C9 | |
| SCHEMBL7784546 | 0.80 | POLB (0.50) | POLBALDH1A1EPHX1NPC1CYP2C9 | |
| SCHEMBL31205836 | 0.79 | DRD2 (0.50) | POLBALDH1A1EPHX1NPC1CYP2C9 | |
| SCHEMBL7790011 | 0.78 | NPC1 (0.56) | POLBALDH1A1EPHX1NPC1RAB9A | |
| SCHEMBL13450330 | 0.77 | POLB (0.62) | POLBALDH1A1EPHX1NPC1CYP2C9 | |
| SCHEMBL7784591 | 0.77 | POLB (0.58) | POLBALDH1A1EPHX1NPC1CYP2C9 | |
| SCHEMBL7790476 | 0.76 | LMNA (0.46) | POLBALDH1A1EPHX1NPC1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |