Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KHK | P50053 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | TYMP | P19971 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12045685 | 0.90 | ADRB1 (0.46) | EPHX2RAB9AADRB1SYK | |
| SCHEMBL10177559 | 0.85 | ADRB1 (0.41) | EPHX2RAB9AADRB1 | |
| SCHEMBL25855629 | 0.85 | ESR1 (0.45) | KHKMAP4K4SYKJAK2TYMP | |
| SCHEMBL21135496 | 0.84 | NOTUM (0.49) | EPHX2ADRB1MAP4K4SYKJAK2 | |
| SCHEMBL6271445 | 0.84 | NOTUM (0.49) | EPHX2ADRB1MAP4K4SYKJAK2 | |
| SCHEMBL21135466 | 0.84 | CYP3A4 (0.56) | RAB9AMAP4K4SYKJAK2TYMP | |
| SCHEMBL77035 | 0.84 | KDM4E (0.49) | RAB9AKHKMAP4K4SYKJAK2 | |
| SCHEMBL21135575 | 0.84 | CYP3A4 (0.56) | RAB9AMAP4K4SYKJAK2TYMP | |
| SCHEMBL21135458 | 0.84 | NOTUM (0.49) | EPHX2ADRB1MAP4K4SYKJAK2 | |
| SCHEMBL7146014 | 0.84 | CYP3A4 (0.56) | RAB9AMAP4K4SYKJAK2TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |