Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21135466 | 1.00 | CYP3A4 (0.56) | CYP3A4CYP2C19NOTUMNPC1RAB9A | |
| SCHEMBL21135575 | 1.00 | CYP3A4 (0.56) | CYP3A4CYP2C19NOTUMNPC1RAB9A | |
| SCHEMBL1812978 | 0.90 | NPC1 (0.62) | CYP3A4CYP2C19NOTUMNPC1RAB9A | |
| SCHEMBL27714650 | 0.90 | NOTUM (0.55) | CYP3A4CYP2C19NOTUMNPC1RAB9A | |
| SCHEMBL25855629 | 0.85 | ESR1 (0.45) | CYP3A4CYP2C19MAP4K4JAK2SYK | |
| SCHEMBL1815810 | 0.85 | CYP3A4 (0.44) | CYP3A4CYP2C19NOTUMFFAR4DEGS1 | |
| SCHEMBL21135496 | 0.84 | NOTUM (0.49) | NOTUMALDH1A1MAPTMAPK1MAP4K4 | |
| SCHEMBL21135458 | 0.84 | NOTUM (0.49) | NOTUMALDH1A1MAPTMAPK1MAP4K4 | |
| SCHEMBL7790528 | 0.84 | EPHX2 (0.51) | RAB9AMAP4K4JAK2SYKTYMP | |
| SCHEMBL77035 | 0.84 | KDM4E (0.49) | CYP3A4CYP2C19NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101974604-A | Method for preparing paroxetine intermediate by enzyme resolution in ionic liquid | NANJING UNIVERSITY OF TECHNOLOGY | 2011-02-16 | — | — | CN | claimed |
| EP-1246821-A2 | PROCESS FOR THE PREPARATION OF PAROXETINE AND SYNTHETIC INTERMEDITATES THEREOF | SmithKline Beecham plc (GB) | 2002-10-09 | — | — | EP | claimed |
| WO-2001004113-A2 | PROCESS FOR THE PREPARATION OF PAROXETINE AND SYNTHETIC INTERMEDITATES THEREOF | SMITHKLINE BEECHAM PLC (GB) | 2001-01-18 | — | — | WO | claimed |
| CN-101360742-A | Substituted phenylpiperidines with serotonin-derived activity and enhanced therapeutic properties | AUSPEX PHARMACEUTICALS INC (US) | 2009-02-04 | — | — | CN | disclosed |
| US-6521758-B2 | Useful in purifying these compounds from the corresponding des-fluoro impurity; making paroxetine | SYNTHON BV (NL) | 2003-02-18 | — | — | US | disclosed |
| US-20020082277-A1 | Tosylate salts of 4-(p-fluorophenyl)-piperidine -3-carbinols | SYNTHON IP INC. | 2002-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082277-A1 | Tosylate salts of 4-(p-fluorophenyl)-piperidine -3-carbinols | HTR3C, HTR5A, HTR3B | CYP3A4 162/4885CYP2C19 39/4885NOTUM 1892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.