Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | GYS1 | P13807 | 5/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | GCGR | P47871 | 3/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | MATK | P42679 | 1/20 | 0.33 |
| ▸ | FRK | P42685 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780920 | 0.90 | PTGS2 (0.51) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL7777792 | 0.82 | GYS1 (0.54) | PTGS2PTGS1GYS1MAPK13MAPK12 | |
| SCHEMBL7773294 | 0.78 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL7778238 | 0.77 | PTGS2 (0.60) | PTGS2PTGS1MAPK14ALOX5GABRP | |
| SCHEMBL7773251 | 0.74 | PTGS2 (0.76) | PTGS2PTGS1 | |
| SCHEMBL7773122 | 0.72 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL7777945 | 0.72 | MAPK14 (0.38) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL7777683 | 0.72 | MAPK14 (0.49) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL8953773 | 0.71 | GYS1 (0.54) | PTGS2PTGS1GYS1MAPK14GCGR | |
| SCHEMBL8758606 | 0.69 | GYS1 (0.38) | PTGS2PTGS1GYS1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772597-B1 | 3,4-SUBSTITUTED PYRAZOLES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2001-12-12 | — | — | EP | disclosed |