Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GYS1 | P13807 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7777792 | 0.87 | GYS1 (0.54) | GYS1MAPTGPR55CNR1CNR2 | |
| SCHEMBL8627994 | 0.80 | LRRK2 (0.46) | GYS1MAPTGPR55CNR1CNR2 | |
| SCHEMBL8953683 | 0.79 | ENPP1 (0.41) | MAPTMEN1KMT2APTGS1PTGS2 | |
| SCHEMBL6721530 | 0.76 | PTGS1 (0.59) | PTGS1PTGS2GCGRMAPK14ALDH1A1 | |
| SCHEMBL8631356 | 0.74 | GYS1 (0.57) | GYS1MAPTGPR55CNR1CNR2 | |
| SCHEMBL8758913 | 0.72 | SLC5A1 (0.46) | GYS1MAPTCNR2PTGS1GCGR | |
| SCHEMBL7778156 | 0.72 | PTGS2 (0.48) | GYS1PTGS1PTGS2 | |
| SCHEMBL3939765 | 0.72 | MAPK14 (0.45) | PTGS1PTGS2GCGRMAPK14ALDH1A1 | |
| SCHEMBL8040640 | 0.72 | PTGS1 (0.44) | PTGS1PTGS2GCGRMAPK14 | |
| SCHEMBL7777308 | 0.71 | LRRK2 (0.57) | GYS1MAPTGPR55CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731794-A1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | SEARLE & CO (US) | 1996-09-18 | — | — | EP | disclosed |
| WO-1995015317-A1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | disclosed |