Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 9/20 | 0.57 |
| ▸ | KIF5B | P33176 | 5/20 | 0.57 |
| ▸ | KDR | P35968 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.42 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1539121 | 0.90 | RET (0.55) | RETKIF5BKDRKDM4EALDH1A1 | |
| SCHEMBL7799232 | 0.81 | CSF1R (0.49) | KDM4EALDH1A1SMN1; SMN2FGFR1RAB9A | |
| SCHEMBL7799235 | 0.80 | CSF1R (0.52) | RETKIF5BKDRKDM4EALDH1A1 | |
| SCHEMBL7799373 | 0.80 | EGFR (0.44) | RETKIF5BKDRKDM4EALDH1A1 | |
| SCHEMBL7791030 | 0.80 | FLT1 (0.55) | KDRKDM4EALDH1A1SMN1; SMN2FGFR1 | |
| SCHEMBL7790969 | 0.80 | EGFR (0.55) | KDM4EALDH1A1SMN1; SMN2FGFR1FGFR4 | |
| SCHEMBL7800417 | 0.80 | LRRK2 (0.53) | KDM4EALDH1A1SMN1; SMN2FGFR1FGFR4 | |
| SCHEMBL7791014 | 0.80 | C1R (0.51) | KDM4EALDH1A1SMN1; SMN2FGFR1FGFR4 | |
| SCHEMBL7753469 | 0.79 | FGFR1 (0.56) | RETKIF5BKDRFGFR1TP53 | |
| SCHEMBL7800394 | 0.78 | AURKA (0.53) | KDM4EFGFR1FGFR4FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163228-A1 | QUINAZOLINES AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-1162974-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056338-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |
| WO-2000056720-A1 | QUINAZOLINES AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |