Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CCNK | O75909 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7791030 | 0.85 | FLT1 (0.55) | CSF1RLRRK2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7800417 | 0.85 | LRRK2 (0.53) | CSF1RLRRK2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7790969 | 0.85 | EGFR (0.55) | CSF1RLRRK2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1539121 | 0.85 | RET (0.55) | LRRK2KDM4EALDH1A1SMN1; SMN2FGFR1 | |
| SCHEMBL7791014 | 0.85 | C1R (0.51) | LRRK2KDM4EALDH1A1SMN1; SMN2FGFR1 | |
| SCHEMBL7799243 | 0.82 | EGFR (0.58) | LRRK2SMN1; SMN2HTTPTK2EGFR | |
| SCHEMBL7757002 | 0.82 | PDGFRB (0.59) | CDK2KDM4EALDH1A1SMN1; SMN2EGFR | |
| SCHEMBL7800595 | 0.81 | LRRK2 (0.46) | LRRK2CCNA2CDK2KDM4EALDH1A1 | |
| SCHEMBL7800394 | 0.81 | AURKA (0.53) | KDM4EFGFR1RAB9APTK2 | |
| SCHEMBL7797381 | 0.81 | KDM4E (0.43) | LRRK2KDM4EALDH1A1SMN1; SMN2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1162974-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-1163228-A1 | QUINAZOLINES AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056338-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |
| WO-2000056720-A1 | QUINAZOLINES AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |