Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1R | P00736 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7799232 | 0.85 | CSF1R (0.49) | ALDH1A1SMN1; SMN2KDM4ELRRK2EGFR | |
| SCHEMBL7800417 | 0.84 | LRRK2 (0.53) | ALDH1A1SMN1; SMN2KDM4ELRRK2EGFR | |
| SCHEMBL7791030 | 0.84 | FLT1 (0.55) | ALDH1A1SMN1; SMN2KDM4ELRRK2EGFR | |
| SCHEMBL7790969 | 0.84 | EGFR (0.55) | ALDH1A1SMN1; SMN2KDM4ELRRK2EGFR | |
| SCHEMBL1539121 | 0.84 | RET (0.55) | ALDH1A1SMN1; SMN2KDM4ELRRK2EGFR | |
| SCHEMBL7799243 | 0.81 | EGFR (0.58) | SMN1; SMN2LRRK2EGFRPTK2KMT2A | |
| SCHEMBL7757002 | 0.81 | PDGFRB (0.59) | ALDH1A1SMN1; SMN2KDM4EEGFRFGFR2 | |
| SCHEMBL7800595 | 0.80 | LRRK2 (0.46) | C1RALDH1A1SMN1; SMN2KDM4ELRRK2 | |
| SCHEMBL7800394 | 0.80 | AURKA (0.53) | KDM4EALKRAB9AFGFR1FGFR2 | |
| SCHEMBL7790973 | 0.80 | RET (0.57) | ALDH1A1SMN1; SMN2KDM4ELRRK2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1162974-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-1163228-A1 | QUINAZOLINES AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056338-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |
| WO-2000056720-A1 | QUINAZOLINES AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |