Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.46 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10596666 | 0.87 | CA4 (0.67) | CA4FAHD1MEN1LDHABLM | |
| Acetic Acid SCHEMBL7699130 | 0.84 | — | — | |
| Bicarbonate SCHEMBL28420909 | 0.80 | CA4 (0.67) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL852 | 0.80 | — | — | |
| Bicarbonate SCHEMBL1332143 | 0.80 | — | — | |
| Formic Acid SCHEMBL6423700 | 0.80 | ALDH1A1 (0.33) | — | |
| Bicarbonate SCHEMBL2275798 | 0.80 | CA4 (0.67) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL142592 | 0.80 | CA4 (0.50) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL2351948 | 0.80 | CA4 (0.67) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL28841434 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013001322-A1 | PROCESS FOR THE SYNTHESIS OF (5α,17β)-N-[(2,5-BIS(TRIFLUOROMETHYL)-PHENYL]-3-OXO-4-AZA-5-ANDROST-1-ENE-17-CARBOXAMIDE | RICHTER GEDEON NYRT. (HU) | 2013-01-03 | — | — | WO | disclosed |
| EP-0897417-B1 | AQUEOUS POTASSIUM FORMATE/ POTASSIUM CARBONATE SOLUTION | LINDE AG (DE) | 2001-10-24 | — | — | EP | disclosed |
| EP-0897417-A1 | AQUEOUS POTASSIUM FORMATE/ POTASSIUM CARBONATE SOLUTION | Linde Aktiengesellschaft (DE) | 1999-02-24 | — | — | EP | disclosed |
| WO-1997042272-A1 | AQUEOUS POTASSIUM FORMATE/ POTASSIUM CARBONATE SOLUTION | LINDE AKTIENGESELLSCHAFT (DE) | 1997-11-13 | — | — | WO | disclosed |