Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3122889 | 0.79 | NPC1 (0.38) | PNMTNPC1RAB9ADRD2DRD4 | |
| Hydrochloric Acid SCHEMBL2354607 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL27425148 | 0.66 | PNMT (0.42) | PNMTNPC1RAB9ADRD2DRD4 | |
| SCHEMBL28066660 | 0.65 | PNMT (0.49) | PNMTNPC1RAB9ADRD2DRD4 | |
| SCHEMBL27348144 | 0.65 | PNMT (0.45) | PNMTNPC1RAB9ADRD2DRD4 | |
| SCHEMBL28973527 | 0.64 | GAA (0.43) | PNMTHTR7 | |
| SCHEMBL28989984 | 0.64 | PNMT (0.47) | PNMTNPC1RAB9A | |
| SCHEMBL28286932 | 0.64 | PNMT (0.44) | PNMTNPC1RAB9ADRD2DRD4 | |
| SCHEMBL28220071 | 0.64 | PNMT (0.44) | PNMTNPC1RAB9ADRD2DRD4 | |
| Hydrochloric Acid SCHEMBL5347439 | 0.64 | PNMT (0.51) | PNMTNPC1RAB9ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1151019-A1 | GERMANIUM BRIDGED METALLOCENES PRODUCING POLYMERS WITH INCREASED MELT STRENGTH | Univation Technologies LLC (US) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000040622-A1 | GERMANIUM BRIDGED METALLOCENES PRODUCING POLYMERS WITH INCREASED MELT STRENGTH | UNIVATION TECHNOLOGIES, LLC (US) | 2000-07-13 | — | — | WO | disclosed |
| US-6034192-A | POLYMERIZING ETHYLENE USING COORDINATION CATALYST | UNIVATION TECHNOLOGIES, LLC (US) | 2000-03-07 | — | — | US | disclosed |