Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | BMP4 | P12644 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3671111 | 0.72 | ALDH1A1 (0.43) | POLBHTTPDE10ANPC1RAB9A | |
| SCHEMBL28947639 | 0.72 | SMPD3 (0.66) | SMPD3AXLCDK2BMP4HTT | |
| SCHEMBL2682919 | 0.71 | SMPD3 (0.55) | SMPD3AXLCDK2BMP4HTT | |
| SCHEMBL30385323 | 0.71 | POLB (0.41) | POLBL3MBTL1HTTSMN1; SMN2NPC1 | |
| SCHEMBL1942256 | 0.70 | PIK3CD (0.44) | SMN1; SMN2ALDH1A1PTGS2DRD3 | |
| SCHEMBL5761567 | 0.70 | TDP1 (0.39) | POLBHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL29088984 | 0.70 | L3MBTL1 (0.38) | POLBL3MBTL1ALDH1A1MAPT | |
| SCHEMBL17747503 | 0.70 | PIK3CA (0.52) | — | |
| SCHEMBL17697728 | 0.69 | SMPD3 (0.51) | SMPD3AXLCDK2BMP4HTT | |
| SCHEMBL15336871 | 0.68 | SMPD3 (0.60) | SMPD3AXLCDK2BMP4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916771-B | Multi-target antitumor compound and preparation method and application thereof | 浙江华海药业股份有限公司 | 2025-04-01 | — | — | CN | disclosed |
| CN-113354649-B | Novel crystal form | 阵列生物制药公司 | 2024-12-10 | — | — | CN | disclosed |
| CN-109414442-B | Liquid preparation of compound | 洛克索肿瘤学股份有限公司 | 2024-03-29 | — | — | CN | disclosed |
| WO-2024046409-A1 | HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2024-03-07 | — | — | WO | disclosed |
| CN-114163445-B | Larotinib intermediate and preparation method thereof | 重庆医科大学 | 2023-06-20 | — | — | CN | disclosed |
| CN-114163445-B | Larotinib intermediate and preparation method thereof | 重庆医科大学 | 2023-06-20 | — | — | CN | disclosed |
| CN-116262739-A | Nitrogen-containing aryl derivative regulator, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-16 | — | — | CN | disclosed |
| CN-111138333-B | Preparation method of (R) -2- (2, 5-difluorophenyl) -pyrrolidine | 上海复星星泰医药科技有限公司 | 2023-05-23 | — | — | CN | disclosed |
| US-20010020310-A1 | Compositions for dyeing keratinous fibres, containing 3-aminopyrazolo[1,5-a]pyrimidines, method of dyeing, and novel 3-aminopyrazolo[1,5-a]pyrimidines | L'OREAL S.A. | 2001-09-13 | — | — | US | disclosed |
| US-6248137-B1 | Compositions for dyeing keratinous fibres, containing 3-aminopyrazolo [1,5-a]pyrimidines, method of dyeing and novel 3-aminopyrazolo [1,5-a]pyrimidines | L'OREAL S.A. (FR) | 2001-06-19 | — | — | US | disclosed |
| EP-0926149-B1 | Keratin fibre dye composition containing 3-aminopyrazolo-(1,5-a)-pyrimidines, dyeing method , 3-aminopyrazolo-(1,5-a)-pyrimidines and their preparation | OREAL (FR) | 2001-03-07 | — | — | EP | disclosed |
| EP-0926149-A1 | Keratin fibre dye composition containing 3-aminopyrazolo-(1,5-a)-pyrimidines, dyeing method , 3-aminopyrazolo-(1,5-a)-pyrimidines and their preparation | L'OREAL (FR) | 1999-06-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010020310-A1 | Compositions for dyeing keratinous fibres, containing 3-aminopyrazolo[1,5-a]pyrimidines, method of dyeing, and novel 3-aminopyrazolo[1,5-a]pyrimidines | DPYD, KRT18, PNPO | SMPD3 4078/4885AXL 1232/4885CDK2 1090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.