Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 5/20 | 0.58 |
| ▸ | PYGM | P11217 | 5/20 | 0.58 |
| ▸ | RIPK1 | Q13546 | 13/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785730 | 0.90 | PYGL (0.56) | PYGLPYGMRIPK1MTNR1AMTNR1B | |
| SCHEMBL8329558 | 0.87 | PYGL (0.53) | PYGLPYGMRIPK1 | |
| SCHEMBL7791600 | 0.84 | CRBN (0.49) | PYGLPYGMRIPK1MTNR1AMTNR1B | |
| SCHEMBL4216634 | 0.83 | PYGL (0.66) | PYGLPYGMRIPK1 | |
| SCHEMBL1976547 | 0.83 | PYGL (0.66) | PYGLPYGMRIPK1 | |
| SCHEMBL4232147 | 0.83 | PYGL (0.66) | PYGLPYGMRIPK1 | |
| SCHEMBL7791794 | 0.83 | RIPK1 (0.46) | PYGLPYGMRIPK1 | |
| SCHEMBL7795529 | 0.79 | SIRT2 (0.46) | PYGLPYGMRIPK1 | |
| SCHEMBL9025583 | 0.79 | PYGL (0.53) | PYGLPYGMRIPK1 | |
| SCHEMBL9025588 | 0.79 | PYGL (0.53) | PYGLPYGMRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |