Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.37 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7790471 | 0.83 | RAB9A (0.37) | L3MBTL3MBTD1L3MBTL1KDM1AL3MBTL4 | |
| SCHEMBL7793294 | 0.78 | HTR3E (0.44) | MEN1KMT2AL3MBTL1POLB | |
| SCHEMBL3146112 | 0.76 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1 | |
| SCHEMBL723225 | 0.74 | ALDH1A1 (0.39) | KMT2AALDH1A1IDO1 | |
| SCHEMBL7172274 | 0.71 | ALDH1A1 (0.46) | MEN1KMT2ATDP1KDM1AALDH1A1 | |
| SCHEMBL7172271 | 0.71 | ALDH1A1 (0.46) | MEN1KMT2ATDP1KDM1AALDH1A1 | |
| SCHEMBL1971584 | 0.71 | ALDH1A1 (0.46) | MEN1KMT2ATDP1KDM1AALDH1A1 | |
| SCHEMBL30102043 | 0.71 | ALDH1A1 (0.46) | MEN1KMT2ATDP1KDM1AALDH1A1 | |
| SCHEMBL8073231 | 0.67 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1IDO1TDO2 | |
| SCHEMBL8004647 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |