Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 17/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 17/20 | 0.46 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.33 |
| ▸ | ITGAM | P11215 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7790950 | 0.98 | ITGB3 (0.45) | ITGB3ITGA2BITGB2ITGAMHTR7 | |
| SCHEMBL7441476 | 0.98 | ITGB3 (0.45) | ITGB3ITGA2BITGB2ITGAMHTR7 | |
| SCHEMBL7790872 | 0.98 | ITGB3 (0.45) | ITGB3ITGA2BITGB2ITGAMHTR7 | |
| SCHEMBL7790913 | 0.98 | ITGB3 (0.45) | ITGB3ITGA2BITGB2ITGAMHTR7 | |
| SCHEMBL7446099 | 0.98 | ITGB3 (0.45) | ITGB3ITGA2BITGB2ITGAMHTR7 | |
| SCHEMBL9095129 | 0.86 | ITGB3 (0.35) | ITGB3ITGA2BITGB2ITGAM | |
| SCHEMBL9093657 | 0.84 | F2 (0.42) | ITGB3ITGA2BITGB2ITGAMHTR7 | |
| SCHEMBL7790968 | 0.83 | ITGB3 (0.46) | ITGB3ITGA2BITGB2ITGAMHTR7 | |
| SCHEMBL9093620 | 0.83 | F2 (0.37) | ITGB3ITGA2BITGB2ITGAM | |
| SCHEMBL9093651 | 0.81 | ITGB3 (0.39) | ITGB3ITGA2BITGB2ITGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832077-B1 | IMPROVED ISOXAZOLINE FIBRINOGEN RECEPTOR ANTAGONISTS | DU PONT PHARM CO (US) | 2001-11-14 | — | — | EP | disclosed |