Hydrochloric Acid

Hydrochloric Acid

SCHEMBL7793942

CC1=Cc2c(ccc3ccccc23)C1[Hf+2]C1C(C)=Cc2c1ccc1ccccc21.[Cl-].[Cl-]

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.38
CYP2A6 P11509 4/20 0.38
KDM4E B2RXH2 2/20 0.37
TSHR P16473 3/20 0.36
CYP1A2 P05177 3/20 0.36
HSD17B10 Q99714 6/20 0.35
TDP1 Q9NUW8 1/20 0.35
HPGD P15428 4/20 0.35
MAPT P10636 2/20 0.35
ALOX12 P18054 1/20 0.35
CYP3A4 P08684 2/20 0.33
HIF1A Q16665 2/20 0.33
HPRT1 P00492 1/20 0.33
MAPK1 P28482 1/20 0.33
CASP1 P29466 1/20 0.33
RAB9A P51151 1/20 0.33
CASP7 P55210 1/20 0.33
ATM Q13315 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
PKM P14618 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7933313 0.90 KDM4E (0.33) ALDH1A1CYP2A6KDM4ETSHRCYP1A2
Hydrochloric Acid SCHEMBL8079749 0.84 ALDH1A1 (0.34) ALDH1A1CYP2A6KDM4EHPGDMAPT
Hydrochloric Acid SCHEMBL3092658 0.78 ALDH1A1 (0.39) ALDH1A1CYP2A6KDM4ETSHRCYP1A2
Hydrochloric Acid SCHEMBL7734464 0.78 ALDH1A1 (0.39) ALDH1A1CYP2A6KDM4ETSHRCYP1A2
Hydrochloric Acid SCHEMBL4063684 0.78 ALDH1A1 (0.39) ALDH1A1CYP2A6KDM4ETSHRCYP1A2
SCHEMBL3965890 0.77 ALDH1A1 (0.42) ALDH1A1CYP2A6KDM4ETSHRCYP1A2
Hydrochloric Acid SCHEMBL7926719 0.77 MAPT (0.34) ALDH1A1KDM4EHSD17B10HPGDMAPT
Hydrochloric Acid SCHEMBL2522928 0.77 ALDH1A1 (0.38) ALDH1A1CYP2A6KDM4ETSHRCYP1A2
Hydrochloric Acid SCHEMBL8853146 0.77 ALDH1A1 (0.38) ALDH1A1CYP2A6KDM4ETSHRCYP1A2
Hydrochloric Acid SCHEMBL8853408 0.77 ALDH1A1 (0.38) ALDH1A1CYP2A6KDM4ETSHRCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5670436-A POLYMERIZATION CATALYSTS HOECHST AG (DE) 1997-09-23 US claimed
EP-0707010-B1 Metallocenes BASELL POLYOLEFINE GMBH (DE) 2001-12-05 EP disclosed
EP-1025134-A1 PROCESS FOR THE PREPARATON OF A CATALYST BOREALIS A/S (DK) 2000-08-09 EP disclosed
WO-1999021895-A1 PROCESS BOREALIS A/S (DK) 1999-05-06 WO disclosed
US-5670436-A POLYMERIZATION CATALYSTS HOECHST AG (DE) 1997-09-23 US disclosed
EP-0707010-A2 Metallocenes HOECHST AKTIENGESELLSCHAFT (DE) 1996-04-17 EP disclosed