Hydrochloric Acid

Hydrochloric Acid

SCHEMBL2522928

CC1=Cc2c(ccc3ccccc23)C1[Zr+2]C1C(C)=Cc2c1ccc1ccccc21.[Cl-].[Cl-]

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.38
CYP2A6 P11509 4/20 0.38
KDM4E B2RXH2 2/20 0.37
TSHR P16473 3/20 0.36
CYP1A2 P05177 3/20 0.36
HSD17B10 Q99714 6/20 0.35
TDP1 Q9NUW8 1/20 0.35
HPGD P15428 4/20 0.35
CYP3A4 P08684 2/20 0.33
HIF1A Q16665 2/20 0.33
HPRT1 P00492 1/20 0.33
MAPK1 P28482 1/20 0.33
CASP1 P29466 1/20 0.33
RAB9A P51151 1/20 0.33
CASP7 P55210 1/20 0.33
ATM Q13315 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
MAPT P10636 2/20 0.32
ALOX12 P18054 1/20 0.32
PKM P14618 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8853408 1.00 ALDH1A1 (0.38) ALDH1A1CYP2A6KDM4ETSHRCYP1A2
Fluoride Ion SCHEMBL7643349 0.97 ALDH1A1 (0.38) ALDH1A1CYP2A6KDM4ETSHRCYP1A2
Hydrochloric Acid SCHEMBL9063494 0.93 KDM4E (0.34) ALDH1A1CYP2A6KDM4ETSHRCYP1A2
Hydrochloric Acid SCHEMBL7935633 0.90 KDM4E (0.33) ALDH1A1CYP2A6KDM4ETSHRCYP1A2
Hydrochloric Acid SCHEMBL8628885 0.88 TNF (0.35) ALDH1A1CYP2A6KDM4ETSHRHSD17B10
Hydrochloric Acid SCHEMBL8853186 0.86 KDM4E (0.32) ALDH1A1CYP2A6KDM4EHSD17B10HPGD
Hydrochloric Acid SCHEMBL3789707 0.86 KDM4E (0.38) ALDH1A1CYP2A6KDM4ETSHRCYP1A2
Hydrochloric Acid SCHEMBL2525067 0.84 CA12 (0.36) ALDH1A1CYP2A6KDM4EHPGDMAPK1
Hydrochloric Acid SCHEMBL5689511 0.84 KDM4E (0.37) ALDH1A1CYP2A6KDM4ETSHRCYP1A2
Fluoride Ion SCHEMBL7639237 0.81 CA12 (0.36) ALDH1A1CYP2A6KDM4EHPGDMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1238026-B2 PIGMENT CONCENTRATES AND METHODS FOR PRODUCTION THEREOF BASF AG (DE) 2007-01-24 EP claimed
US-6441111-B1 MULTISTAGE POLYMERIZATION WHERE CONDITIONS ARE STEPWISE CHANGED IN THE PRESENCE OF A SUPPORTED METALLOCENE CATALYST OF GIVEN TRANSITION METAL COMPOUND AND AN ALUMOXANE ON A FINELY PARTICULATE SUPPORT, AND AN ORGANOALUMINUM COMPOUND CHISSO CORPORATION (JP) 2002-08-27 US claimed
US-5670436-A POLYMERIZATION CATALYSTS HOECHST AG (DE) 1997-09-23 US claimed
JP-8193092-A None JP disclosed
EP-3438183-B1 POLYETHYLENE AND MOLDED BODY THEREOF JAPAN POLYETHYLENE CORP (JP) 2023-11-22 EP disclosed
US-10377886-B2 Polyethylene for pipe and joint, and molded body thereof JAPAN POLYETHYLENE CORPORATION (JP) 2019-08-13 US disclosed
EP-3438183-A1 POLYETHYLENE AND MOLDED BODY OF SAME Japan Polypropylene Corporation (JP) 2019-02-06 EP disclosed
US-20180112070-A1 POLYETHYLENE FOR PIPE AND JOINT, AND MOLDED BODY THEREOF JAPAN POLYETHYLENE CORPORATION (JP) 2018-04-26 US disclosed
EP-2033975-B1 Catalyst composition BASELL POLYOLEFINE GMBH (DE) 2014-05-14 EP disclosed
US-8039569-B2 Polyethylene molding compositions for injection molding applications BASELL POLYOLEFINE GMBH (DE) 2011-10-18 US disclosed
EP-1874830-B1 MOLDING COMPOSITION COMPRISING POLYETHYLENE FOR PREPARING FILMS AND PROCESS FOR PREPARING THE MOLDING COMPOSITION IN THE PRESENCE OF A MIXED CATALYST BASELL POLYOLEFINE GMBH (DE) 2010-10-20 EP disclosed
EP-1004603-B1 POLYDISPERSE PROPYLENE POLYMER AND PROCESS FOR PRODUCING THE SAME CHISSO CORP (JP) 2003-01-15 EP disclosed
EP-1263847-A1 PROCESS FOR THE PREPARATION OF ADDITIVE COATED MOLDING POWDER Borealis Technology Oy (FI) 2002-12-11 EP disclosed
US-20020004447-A1 Olefin polymerization catalyst and method for polymerizing olefin using the same JAPAN POLYCHEM CORPORATION (JP) 2002-01-10 US disclosed
EP-1160261-A1 Olefin polymerization catalyst and method for polymerizing olefin using the same Japan Polychem Corporation (JP) 2001-12-05 EP disclosed
WO-2001062832-A1 PROCESS FOR THE PREPARATION OF ADDITIVE COATED MOLDING POWDER BOREALIS TECHNOLOGY OY (FI) 2001-08-30 WO disclosed
US-6153549-A COORDINATION POLYMERIZATION CATALYSTS TARGOR GMBH (DE) 2000-11-28 US disclosed
US-5883275-A Process for the hydrogenation of metallocenes TARGOR GMBH (DE) 1999-03-16 US disclosed
US-5670436-A POLYMERIZATION CATALYSTS HOECHST AG (DE) 1997-09-23 US disclosed
JP-H08193092-A METALLOCENE COMPOUND HOECHST AG 1996-07-30 JP disclosed