Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7784550 | 0.81 | KCNH3 (0.51) | MAPTL3MBTL1MEN1KMT2AMAPK1 | |
| SCHEMBL11527128 | 0.81 | L3MBTL1 (0.57) | MAPTL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL11529228 | 0.80 | L3MBTL1 (0.56) | MAPTL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL19464345 | 0.78 | L3MBTL1 (0.55) | MAPTL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL11531506 | 0.77 | L3MBTL1 (0.60) | MAPTL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL11529335 | 0.77 | L3MBTL1 (0.60) | MAPTL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL11532725 | 0.73 | ALDH1A1 (0.72) | MAPTL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL20632768 | 0.73 | ALDH1A1 (0.72) | MAPTL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL15325741 | 0.72 | L3MBTL1 (0.55) | MAPTL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL29008517 | 0.72 | MAPT (0.54) | MAPTL3MBTL1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |