SCHEMBL7794352

SCHEMBL7794352

CCO[SiH2]OCCc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 0.42
ATM Q13315 1/20 0.42
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
IDO1 P14902 1/20 0.39
TP53 P04637 1/20 0.39
RAB9A P51151 2/20 0.39
NPC1 O15118 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
ALDH1A1 P00352 1/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
ALOX12 P18054 1/20 0.38
CASP1 P29466 1/20 0.38
HSD17B10 Q99714 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
SIGMAR1 Q99720 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9137845 0.90 TAAR1 (0.46) TAAR1ATMTP53L3MBTL1MEN1
SCHEMBL1512799 0.89 IDO1 (0.50) TAAR1ATMIDO1L3MBTL1MEN1
SCHEMBL8019889 0.86 TAAR1 (0.43) TAAR1ATMTP53L3MBTL1MEN1
SCHEMBL7174815 0.79 TSHR (0.46) CA1CA2CA9IDO1TP53
SCHEMBL705288 0.78 CA1 (0.41) TAAR1ATMCA1CA2CA9
SCHEMBL4604272 0.78 CA1 (0.41) TAAR1CA1CA2CA9IDO1
SCHEMBL704523 0.77 CA1 (0.44) TAAR1ATMCA1CA2CA9
Biphenyl SCHEMBL34936 0.76 ALDH1A1 (0.45) TAAR1IDO1TP53RAB9ANPC1
SCHEMBL5666722 0.76 TAAR1 (0.47) TAAR1CA1CA2CA9IDO1
SCHEMBL28729766 0.76 NPC1 (0.43) TAAR1CA1CA2CA9IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0698632-B1 Process for preparing organosiloxane terminated with silanol group SHINETSU CHEMICAL CO (JP) 2001-11-21 EP disclosed