SCHEMBL7794974

SCHEMBL7794974

COc1c(C)cc(C(=O)O)cc1C1(C)CCCCC1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RARB P10826 6/20 0.49
RARG P13631 6/20 0.49
RARA P10276 4/20 0.49
TPMT P51580 4/20 0.39
PTGDR Q13258 1/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.38
RXRA P19793 7/20 0.37
HNF4A P41235 1/20 0.37
KMT2A Q03164 1/20 0.37
RXRB P28702 4/20 0.37
RXRG P48443 4/20 0.37
CNR2 P34972 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7786557 0.83 RARB (0.47) RARBRARGRARATPMTPTGDR
SCHEMBL7942020 0.81 SLC29A1 (0.38) RARBRARGRARAPTGDRPTGDR2
SCHEMBL3810035 0.81 RARB (0.50) RARBRARGRARAPTGDRPTGDR2
SCHEMBL7794887 0.80 PTGDR (0.43) RARBRARGRARAPTGDRPTGDR2
SCHEMBL8401582 0.79 AKR1C3 (0.39) RARBRARGRARAPTGDRPTGDR2
SCHEMBL7933771 0.78 RARB (0.39) RARBRARGRARAPTGDRPTGDR2
SCHEMBL7794944 0.78 THRA (0.41) RARBRARGRARAPTGDRPTGDR2
SCHEMBL14273036 0.77 RARB (0.55) RARBRARGRARAPTGDRPTGDR2
SCHEMBL7933908 0.77 PTGDR (0.36) RARBRARGRARAPTGDRPTGDR2
SCHEMBL312132 0.76 TPMT (0.55) TPMTKMT2ACNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0823435-B1 Phosphites, process for producing the same and their use SUMITOMO CHEMICAL CO (JP) 2001-11-21 EP disclosed
US-6242514-B1 CYCLIC PHOSPHATE OR PHOSPHONATE; HEAT AND OXIDATION STABILIZER ESPECIALLY FOR OLEFIN POLYMERS AND ENGINEERING THERMOPLASTICS SUMITOMO CHEMICAL COMPANY, LTD. (JP) 2001-06-05 US disclosed
US-5914361-A IMPART HEAT STABILITY TO ORGANIC MATERIALS, INCLUDING POLYOLEFINS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-06-22 US disclosed
US-5889095-A OXYGEN AND HEAT RESISTANCE SUMITOMO CHEMICAL COMPANY, LTD. (JP) 1999-03-30 US disclosed
EP-0823435-A2 Phosphites, process for producing the same and their use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-02-11 EP disclosed