Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.52 |
| ▸ | TK1 | P04183 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.41 |
| ▸ | DUT | P33316 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13314244 | 1.00 | TOP2A (0.52) | TOP2ATK1BCHEHDAC1DUT | |
| SCHEMBL13314142 | 1.00 | TOP2A (0.52) | TOP2ATK1BCHEHDAC1DUT | |
| SCHEMBL13533902 | 1.00 | TOP2A (0.52) | TOP2ATK1BCHEHDAC1DUT | |
| SCHEMBL17525801 | 0.92 | TK1 (0.51) | TOP2ATK1BCHE | |
| SCHEMBL23734350 | 0.91 | TOP2A (0.51) | TOP2ATK1BCHEHDAC1DUT | |
| SCHEMBL24823002 | 0.91 | TOP2A (0.51) | TOP2ATK1BCHEHDAC1DUT | |
| SCHEMBL24825163 | 0.89 | TOP2A (0.50) | TOP2ATK1BCHEHDAC1DUT | |
| SCHEMBL23734310 | 0.89 | TOP2A (0.50) | TOP2ATK1BCHEHDAC1DUT | |
| SCHEMBL23734365 | 0.89 | TOP2A (0.50) | TOP2ATK1BCHEHDAC1DUT | |
| SCHEMBL21902479 | 0.89 | TK1 (0.63) | TK1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809357-B2 | Compounds and derivatizations of DNAs and RNAs on the nucleobases of pyrimidines for function, structure and therapeutics | HUANG, ZHEN, DR. | 2014-08-19 | — | — | US | disclosed |
| US-20120070825-A1 | Novel Compounds and Derivatizations of DNAs and RNAs on the Nucleobases of Pyrimidines for Function, Structure and Therapeutics | SENA RESEARCH, INC. (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120070825-A1 | Novel Compounds and Derivatizations of DNAs and RNAs on the Nucleobases of Pyrimidines for Function, Structure and Therapeutics | NSUN2, RNMT, TRDMT1 | TOP2A 260/4885TK1 59/4885BCHE 3006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.