Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | MPI | P34949 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27617272 | 0.82 | HSD17B3 (0.61) | GPR35KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL125671 | 0.81 | HSD17B3 (0.71) | KDM4EALDH1A1MEN1KMT2AAKR1B1 | |
| SCHEMBL7944663 | 0.76 | SRC (0.53) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL6478947 | 0.73 | KDM4E (0.61) | GPR35KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6578090 | 0.73 | CA12 (0.64) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL14437117 | 0.72 | MAPT (0.42) | ALDH1A1MEN1KMT2AHPGDMAPT | |
| SCHEMBL27554307 | 0.71 | ALDH1A1 (0.49) | GPR35KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL27872231 | 0.71 | HSD17B3 (0.71) | KDM4EALDH1A1MEN1KMT2AAKR1B1 | |
| SCHEMBL8374891 | 0.71 | HSD17B3 (0.61) | GPR35KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7797760 | 0.71 | KDM4E (0.71) | GPR35KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900230-B1 | ESCULETIN DERIVATIVES | IDG UK LTD (GB) | 2001-12-12 | — | — | EP | disclosed |
| US-6287798-B1 | COMPOUND WHICH IS HYDROLYZABLE BY MICROORGANISMS FOR DETECTION IN SAMPLES; FORMS BLACK, INSOLUBLE, NONDIFFUSABLE COMPOUND | IDG (UK) LIMITED (GB) | 2001-09-11 | — | — | US | disclosed |
| US-6008008-A | 6- OR 7-SUBSTITUTED DERIVATIVES WHICH ARE MICROBIALLY HYDROLYZABLE TO FLUORESCENT, IRON CHELATING MOIETIES WHICH ARE NONDIFFUSING IN AGAR AND OTHER AQUEOUS ENVIRONMENTS; FOR DETECTION OF MICROORGANISMS | IDG (UK) LIMITED (GB) | 1999-12-28 | — | — | US | disclosed |
| EP-0900230-A2 | ESCULETIN DERIVATIVES | IDG (UK) Limited (GB) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997041138-A2 | ESCULETIN DERIVATIVES | IDG (UK) LIMITED (GB) | 1997-11-06 | — | — | WO | disclosed |