Sugi Predict

Sugi Predict / Compounds / SCHEMBL7795435

SCHEMBL7795435

SCHEMBL7795435

O=C1Nc2cccc(I)c21

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP2 O95551 1/20 0.53
▸ CES1 P23141 3/20 0.48
▸ PDGFRA P16234 2/20 0.40
▸ FER P16591 2/20 0.40
▸ LTK P29376 2/20 0.40
▸ ACVR1 Q04771 2/20 0.40
▸ DYRK1B Q9Y463 2/20 0.40
▸ MAOA P21397 1/20 0.40
▸ MAOB P27338 1/20 0.40
▸ CDK8 P49336 1/20 0.40
▸ LRRK2 Q5S007 1/20 0.40
▸ KDR P35968 3/20 0.39
▸ PDPK1 O15530 2/20 0.39
▸ TGM2 P21980 5/20 0.38
▸ RET P07949 3/20 0.37
▸ MAP4K4 O95819 2/20 0.37
▸ FGFR1 P11362 2/20 0.37
▸ FLT1 P17948 2/20 0.37
▸ CSNK1A1 P48729 2/20 0.37
▸ GSK3A P49840 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2838571 0.87 CES1 (0.60) TDP2CES1PDGFRAFERLTK
SCHEMBL30835279 0.87 CES1 (0.60) TDP2CES1PDGFRAFERLTK
SCHEMBL2932679 0.76 GSK3B (0.52) TDP2PDGFRAFERLTKACVR1
SCHEMBL2512919 0.75 SMN1; SMN2 (0.59) TDP2CES1KDRPDPK1TGM2
SCHEMBL12200893 0.75 SMN1; SMN2 (0.59) TDP2CES1KDRPDPK1TGM2
SCHEMBL6967576 0.73 PDPK1 (0.72) PDGFRALTKDYRK1BLRRK2KDR
SCHEMBL6967581 0.73 PDPK1 (0.72) PDGFRALTKDYRK1BLRRK2KDR
SCHEMBL1270125 0.73 CES1 (0.48) CES1PDGFRAFERLTKACVR1
SCHEMBL2331366 0.73 PDPK1 (0.54) CES1PDGFRAFERLTKACVR1
SCHEMBL18010796 0.70 TDP2 (1.00) TDP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3508484-B1 HETEROCYCLIC AMIDES AS KINASE INHIBITORS GLAXOSMITHKLINE IP DEV LTD (GB) 2021-04-07 — — EP disclosed
US-10940154-B2 Heterocyclic amides as kinase inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2021-03-09 — — US disclosed
US-10933070-B2 Heterocyclic amides as kinase inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2021-03-02 — — US disclosed
EP-3342771-B1 HETEROCYCLIC AMIDES AS KINASE INHIBITORS GLAXOSMITHKLINE IP DEV LTD (GB) 2020-11-25 — — EP disclosed
EP-3375780-B1 HETEROCYCLIC AMIDES AS KINASE INHIBITORS GLAXOSMITHKLINE IP DEV LTD (GB) 2020-06-03 — — EP disclosed
US-20190262356-A1 HETEROCYCLIC AMIDES AS KINASE INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-08-29 — — US disclosed
EP-3508484-A1 HETEROCYCLIC AMIDES AS KINASE INHIBITORS GlaxoSmithKline Intellectual Property Development Limited (GB) 2019-07-10 — — EP disclosed
US-20190201413-A1 HETEROCYCLIC AMIDES AS KINASE INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-07-04 — — US disclosed
US-10292987-B2 Heterocyclic amides as kinase inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-05-21 — — US disclosed
CN-108774214-A Heterocyclic amides as kinase inhibitors 葛兰素史密斯克莱知识产权发展有限公司 2018-11-09 — — CN disclosed
US-5317017-A N-biphenyl-3-amido substituted benzolactams stimulate growth hormone release MERCK & CO., INC. (US) 1994-05-31 — — US disclosed
US-5310737-A Benzo-fused lactams that promote the release of growth hormone MERCK & CO., INC. (US) 1994-05-10 — — US disclosed
WO-1994007483-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-04-14 — — WO disclosed
WO-1994007486-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-04-14 — — WO disclosed
WO-1994005634-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-03-17 — — WO disclosed
US-5284841-A Benzo-fused lactams promote release of growth hormone MERCK & CO., INC. (US) 1994-02-08 — — US disclosed
US-5283241-A Animal growth regulators MERCK & CO., INC. (US) 1994-02-01 — — US disclosed
US-5206235-A Animal growth regulators; stimulants MERCK & CO., INC. (US) 1993-04-27 — — US disclosed
EP-0513974-A1 Novel benzo-fused lactams that promote the release of growth hormone MERCK & CO. INC. (US) 1992-11-19 — — EP disclosed
WO-1992016524-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1992-10-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190201413-A1 HETEROCYCLIC AMIDES AS KINASE INHIBITORS CNKSR1, ARAF, MAP4K2 TDP2 2706/4885CES1 1730/4885PDGFRA 860/4885
US-10940154-B2 Heterocyclic amides as kinase inhibitors CNKSR1, ARAF, MAP4K2 TDP2 2706/4885CES1 1730/4885PDGFRA 860/4885
US-20190262356-A1 HETEROCYCLIC AMIDES AS KINASE INHIBITORS CNKSR1, ARAF, MAP4K2 TDP2 2706/4885CES1 1730/4885PDGFRA 860/4885
US-10933070-B2 Heterocyclic amides as kinase inhibitors CNKSR1, ARAF, MAP4K2 TDP2 2706/4885CES1 1730/4885PDGFRA 860/4885
US-10292987-B2 Heterocyclic amides as kinase inhibitors CNKSR1, ARAF, MAP4K2 TDP2 2706/4885CES1 1730/4885PDGFRA 860/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.