Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 10/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 2/20 | 0.38 |
| ▸ | PYGM | P11217 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8331733 | 0.90 | RIPK1 (0.42) | RIPK1CA1CA2ACHEPYGL | |
| SCHEMBL8332959 | 0.89 | RIPK1 (0.49) | RIPK1CA1CA2ACHEPYGL | |
| SCHEMBL7794597 | 0.87 | RIPK1 (0.40) | RIPK1PYGLPYGM | |
| SCHEMBL7932739 | 0.81 | RIPK1 (0.38) | RIPK1CA1CA2ACHEIDO1 | |
| SCHEMBL8330863 | 0.77 | RIPK1 (0.45) | RIPK1PYGLPYGM | |
| SCHEMBL9025122 | 0.77 | RIPK1 (0.48) | RIPK1CA1CA2ACHEPYGL | |
| SCHEMBL7421739 | 0.77 | RIPK1 (0.48) | RIPK1CA1CA2ACHEPYGL | |
| SCHEMBL9026043 | 0.77 | RIPK1 (0.48) | RIPK1CA1CA2ACHEPYGL | |
| SCHEMBL9025094 | 0.77 | RIPK1 (0.48) | RIPK1CA1CA2ACHEPYGL | |
| SCHEMBL1976229 | 0.76 | RIPK1 (0.57) | RIPK1CA1CA2ACHEPYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5968924-A | HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS | MERCK & CO., INC. (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |