Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | PYGM | P11217 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7795967 | 0.87 | RIPK1 (0.42) | RIPK1PYGLPYGM | |
| SCHEMBL8331733 | 0.87 | RIPK1 (0.42) | RIPK1PYGLPYGM | |
| SCHEMBL8332959 | 0.86 | RIPK1 (0.49) | RIPK1PYGLPYGM | |
| SCHEMBL7932739 | 0.78 | RIPK1 (0.38) | RIPK1 | |
| SCHEMBL7795529 | 0.75 | SIRT2 (0.46) | RIPK1SIRT2PYGLPYGM | |
| SCHEMBL9025094 | 0.74 | RIPK1 (0.48) | RIPK1PYGLPYGM | |
| SCHEMBL9026043 | 0.74 | RIPK1 (0.48) | RIPK1PYGLPYGM | |
| SCHEMBL7421739 | 0.74 | RIPK1 (0.48) | RIPK1PYGLPYGM | |
| SCHEMBL9025122 | 0.74 | RIPK1 (0.48) | RIPK1PYGLPYGM | |
| SCHEMBL1976229 | 0.74 | RIPK1 (0.57) | RIPK1PYGLPYGM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5968924-A | HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS | MERCK & CO., INC. (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |