Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MLYCD | O95822 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8716747 | 0.89 | CREBBP (0.52) | MAPTSMN1; SMN2TP53GAACREBBP | |
| SCHEMBL8714422 | 0.80 | ALDH1A1 (0.50) | MAPTSMN1; SMN2TP53GAAKMT2A | |
| SCHEMBL32681294 | 0.79 | HDAC1 (0.49) | MAPTSMN1; SMN2GAACREBBPKMT2A | |
| SCHEMBL3809200 | 0.79 | KMT2A (0.48) | MAPTSMN1; SMN2GAACREBBPKMT2A | |
| SCHEMBL9232831 | 0.78 | KMT2A (0.51) | SMN1; SMN2GAACREBBPKMT2AMEN1 | |
| SCHEMBL8716505 | 0.77 | KMT2A (0.65) | MAPTSMN1; SMN2TP53GAAKMT2A | |
| SCHEMBL7796030 | 0.76 | ITGB1 (0.43) | SMN1; SMN2CREBBPKMT2AMEN1ALDH1A1 | |
| SCHEMBL8711253 | 0.75 | ALDH1A1 (0.62) | MAPTGAAKMT2AMEN1ALDH1A1 | |
| SCHEMBL3811958 | 0.75 | KMT2A (0.64) | CREBBPKMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL393604 | 0.74 | MEN1 (0.44) | SMN1; SMN2GAACREBBPKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |