Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7795958 | 1.00 | TDP1 (0.43) | TDP1HTR2CPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL7796218 | 0.99 | HTR2C (0.44) | TDP1HTR2CPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL7796421 | 0.97 | ALDH1A1 (0.45) | TDP1HTR2CPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL7792226 | 0.97 | ALDH1A1 (0.45) | TDP1HTR2CPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL7795926 | 0.96 | POLB (0.47) | HTR2CPOLB | |
| Hydrochloric Acid SCHEMBL7792164 | 0.95 | POLB (0.46) | HTR2CPOLB | |
| SCHEMBL7796456 | 0.95 | LTA4H (0.44) | TDP1HTR2CPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL7792361 | 0.95 | CYP2D6 (0.44) | KDM4ESMN1; SMN2ADORA2AADORA1CYP2D6 | |
| SCHEMBL7795918 | 0.94 | LTA4H (0.44) | TDP1HTR2CKDM4ESMN1; SMN2ADORA2A | |
| SCHEMBL7792004 | 0.94 | ALDH1A1 (0.45) | KDM4ESMN1; SMN2ADORA2AADORA1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |