Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7794709 | 0.99 | HRH3 (0.55) | HRH3KCNH2ADORA2AADORA2BADORA1 | |
| SCHEMBL27494797 | 0.97 | HRH3 (0.53) | HRH3KCNH2ADORA2AADORA2BADORA1 | |
| SCHEMBL7792408 | 0.97 | HRH3 (0.52) | HRH3KCNH2ADORA2AADORA2BADORA1 | |
| SCHEMBL7786144 | 0.96 | LTA4H (0.51) | HRH3ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL27514549 | 0.95 | HRH3 (0.50) | HRH3KCNH2ADORA2AADORA2BADORA1 | |
| SCHEMBL7786054 | 0.95 | HRH3 (0.53) | HRH3KCNH2ADORA2AADORA2BADORA1 | |
| SCHEMBL7791989 | 0.94 | ALDH1A1 (0.53) | HRH3KCNH2ADORA2AADORA2BADORA1 | |
| SCHEMBL7792420 | 0.92 | HRH3 (0.51) | HRH3ADORA2AADORA1KDM4EALDH1A1 | |
| SCHEMBL7794749 | 0.91 | HRH3 (0.57) | HRH3KCNH2ADORA2AADORA2BADORA1 | |
| SCHEMBL27514547 | 0.91 | ALDH1A1 (0.53) | HRH3KCNH2ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |