SCHEMBL7796405

SCHEMBL7796405

CCN(CC)C(=O)c1cc(OC)cc(OC)c1-c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 5/20 0.49
LMNA P02545 5/20 0.49
TSHR P16473 3/20 0.49
KMT2A Q03164 5/20 0.48
MEN1 O00255 4/20 0.48
ALDH1A1 P00352 3/20 0.47
KDM4E B2RXH2 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
MAPT P10636 2/20 0.46
CYP1A2 P05177 1/20 0.44
HSP90AA1 P07900 1/20 0.44
HSP90AB1 P08238 1/20 0.44
BLM P54132 1/20 0.44
PTPN1 P18031 1/20 0.43
KEAP1 Q14145 1/20 0.43
LPAR1 Q92633 1/20 0.43
LPAR5 Q9H1C0 1/20 0.43
TDP1 Q9NUW8 2/20 0.43
TRPV1 Q8NER1 1/20 0.43
NPC1 O15118 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14052439 0.82 KEAP1 (0.56) HPGDLMNATSHRKMT2AMEN1
SCHEMBL14052589 0.82 HPGD (0.46) HPGDLMNATSHRKMT2AMEN1
SCHEMBL16516551 0.79 LMNA (0.49) HPGDLMNATSHRKMT2AMEN1
SCHEMBL14052448 0.78 HPGD (0.54) HPGDLMNATSHRKMT2AMEN1
SCHEMBL7198038 0.77 LMNA (0.54) HPGDLMNATSHRKMT2AMEN1
SCHEMBL14052438 0.77 HPGD (0.56) HPGDLMNATSHRKMT2AMEN1
SCHEMBL8567749 0.76 SMN1; SMN2 (0.54) HPGDLMNAKMT2AMEN1ALDH1A1
SCHEMBL7291892 0.76 NPC1 (0.55) HPGDLMNATSHRKMT2AMEN1
SCHEMBL8901809 0.76 MAPT (0.57) HPGDLMNATSHRKMT2AMEN1
SCHEMBL14052395 0.76 KMT2A (0.55) HPGDLMNATSHRKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0906268-B1 ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS AVENTIS PHARMA INC (US) 2001-11-28 EP disclosed
US-6004959-A HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS HOECHST MARION ROUSSEL, INC. (US) 1999-12-21 US disclosed
EP-0906268-A1 ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS HOECHST MARION ROUSSEL, INC. (US) 1999-04-07 EP disclosed
WO-1997045397-A1 ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS HOECHST MARION ROUSSEL, INC. (US) 1997-12-04 WO disclosed