Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hippuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.66 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | PTPRC | P08575 | 2/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hippuric Acid SCHEMBL657588 | 1.00 | KDM4E (0.66) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL428479 | 0.98 | GAA (0.68) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL22030672 | 0.98 | GAA (0.68) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL7486 | 0.98 | GAA (0.68) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL1458080 | 0.96 | MAPT (0.66) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL21569381 | 0.96 | MAPT (0.66) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL1179259 | 0.96 | MAPT (0.66) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL3448563 | 0.96 | MAPT (0.66) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL7398337 | 0.96 | MAPT (0.66) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL11656206 | 0.96 | MAPT (0.66) | KDM4EMAPTHIF1ASLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107921112-A | methods of modulating L GA L S3BP for treatment of systemic lupus erythematosus | 默克专利有限公司 | 2018-04-17 | — | — | CN | claimed |
| US-20130234071-A1 | COMPOSITION OF HUMAN SYNTHETIC URINE | DENEAU JOEL DAVID (US) | 2013-09-12 | — | — | US | claimed |
| US-6319683-B1 | CARBONYLATION WITH FORMALDEHYDE | INTERGEN COMPANY | 2001-11-20 | — | — | US | claimed |
| US-20010031482-A1 | Method and composition for controlling formaldehyde fixation by delayed quenching | JAMES WILLIAM M (US) | 2001-10-18 | — | — | US | claimed |
| US-6072086-A | QUENCHING AQUEOUS FORMALDEHYDE SOLUTION WITH COMPOSITION COMPRISING FIRST AGENT CAPABLE OF REACTING WITH FORMALDEHYDE, SECOND AGENT CAPABLE OF SUBSTANTIALLY PREVENTING FIRST AGENT FROM REACTING WITH FORMALDEHYDE FOR FINITE TIME PERIOD | INTERGEN COMPANY (US) | 2000-06-06 | — | — | US | claimed |
| EP-0900367-A1 | METHOD AND COMPOSITION FOR CONTROLLING FORMALDEHYDE FIXATION BY DELAYED QUENCHING | ONCOR, INC. (US) | 1999-03-10 | — | — | EP | claimed |
| WO-1997039330-A1 | METHOD AND COMPOSITION FOR CONTROLLING FORMALDEHYDE FIXATION BY DELAYED QUENCHING | ONCOR, INC. (US) | 1997-10-23 | — | — | WO | claimed |
| US-20250135061-A1 | Devices for Retaining Bodily Fluids with pH Control Components | CUPRON, INC. (US) | 2025-05-01 | — | — | US | disclosed |
| CN-118714929-A | Device for trapping body fluids with pH controlling component | 科普隆有限公司 | 2024-09-27 | — | — | CN | disclosed |
| EP-4376619-A1 | DEVICES FOR RETAINING BODILY FLUIDS WITH PH CONTROL COMPONENTS | Cupron Inc. (US) | 2024-06-05 | — | — | EP | disclosed |
| WO-2024035380-A1 | DEVICES FOR RETAINING BODILY FLUIDS WITH PH CONTROL COMPONENTS | CUPRON INC. (US) | 2024-02-15 | — | — | WO | disclosed |
| CN-107074768-A | The Pyridione derivatives of (RET) kinase inhibitor are reset as transfection | 葛兰素史克知识产权发展有限公司 | 2017-08-18 | — | — | CN | disclosed |
| US-9117756-B2 | Encapsulant with corrosion inhibitor | FREESCALE SEMICONDUCTOR, INC. (US) | 2015-08-25 | — | — | US | disclosed |
| US-20130193576-A1 | ENCAPSULANT WITH COROSION INHIBITOR | NXP, B.V. F/K/A FREESCALE SEMICONDUCTOR, INC. (NL) | 2013-08-01 | — | — | US | disclosed |
| EP-2620979-A2 | Encapsulant with corosion inhibitor | Freescale Semiconductor, Inc. (US) | 2013-07-31 | — | — | EP | disclosed |
| US-6319683-B1 | CARBONYLATION WITH FORMALDEHYDE | INTERGEN COMPANY | 2001-11-20 | — | — | US | disclosed |
| US-20010031482-A1 | Method and composition for controlling formaldehyde fixation by delayed quenching | JAMES WILLIAM M (US) | 2001-10-18 | — | — | US | disclosed |
| US-6072086-A | QUENCHING AQUEOUS FORMALDEHYDE SOLUTION WITH COMPOSITION COMPRISING FIRST AGENT CAPABLE OF REACTING WITH FORMALDEHYDE, SECOND AGENT CAPABLE OF SUBSTANTIALLY PREVENTING FIRST AGENT FROM REACTING WITH FORMALDEHYDE FOR FINITE TIME PERIOD | INTERGEN COMPANY (US) | 2000-06-06 | — | — | US | disclosed |
| EP-0900367-A1 | METHOD AND COMPOSITION FOR CONTROLLING FORMALDEHYDE FIXATION BY DELAYED QUENCHING | ONCOR, INC. (US) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997039330-A1 | METHOD AND COMPOSITION FOR CONTROLLING FORMALDEHYDE FIXATION BY DELAYED QUENCHING | ONCOR, INC. (US) | 1997-10-23 | — | — | WO | disclosed |