Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL318178 | 1.00 | MAPT (0.39) | MAPTKDM4EALOX15SMN1; SMN2MAPK1 | |
| Trolamine SCHEMBL8884366 | 1.00 | MAPT (0.39) | MAPTKDM4EALOX15SMN1; SMN2MAPK1 | |
| Trolamine SCHEMBL27412368 | 1.00 | MAPT (0.39) | MAPTKDM4EALOX15SMN1; SMN2MAPK1 | |
| Trolamine SCHEMBL5874691 | 1.00 | MAPT (0.39) | MAPTKDM4EALOX15SMN1; SMN2MAPK1 | |
| Trolamine SCHEMBL22288216 | 0.97 | MAPT (0.37) | MAPTKDM4EALOX15SMN1; SMN2MAPK1 | |
| Trolamine SCHEMBL7564590 | 0.97 | MAPT (0.37) | MAPTKDM4EALOX15SMN1; SMN2MAPK1 | |
| Trolamine SCHEMBL28289278 | 0.94 | MAPT (0.41) | MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL28297813 | 0.91 | MAPT (0.39) | MAPTKDM4EALOX15SMN1; SMN2MAPK1 | |
| Trolamine SCHEMBL5084486 | 0.89 | KDM4E (0.38) | MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL11775360 | 0.88 | MAPT (0.36) | MAPTKDM4EALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6102995-A | High performance intumescent system for imparting heat/flame resistance to thermally unstable substrates | GEORGIA-PACIFIC RESINS, INC. (US) | 2000-08-15 | — | — | US | claimed |
| EP-0951496-B1 | ALKYD AND ARALKYD DERIVATIVES OF PHENOLIC POLYMERS | GEORGIA PACIFIC RESINS (US) | 2001-12-19 | — | — | EP | disclosed |
| US-6102995-A | High performance intumescent system for imparting heat/flame resistance to thermally unstable substrates | GEORGIA-PACIFIC RESINS, INC. (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0951496-A2 | ALKYD AND ARALKYD DERIVATIVES OF PHENOLIC POLYMERS | GEORGIA-PACIFIC RESINS, INC. (US) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998030596-A2 | ALKYD AND ARALKYD DERIVATIVES OF PHENOLIC POLYMERS | GEORGIA-PACIFIC RESINS, INC. (US) | 1998-07-16 | — | — | WO | disclosed |
| US-5770750-A | Alkyd and aralkyd derivatives of phenolic polymers | GEORGIA-PACIFIC RESINS, INC. (US) | 1998-06-23 | — | — | US | disclosed |
| EP-0193369-B1 | POLYMER ARTICLE AND ITS USE FOR CONTROLLED INTRODUCTION OF REAGENT INTO A FLUID | EXXON CHEMICAL PATENTS INC. (US) | 1990-08-08 | — | — | EP | disclosed |
| US-4159922-A | NITRILOTRIS/METHYL PHOSPHONIC ACID/, 2-PHOSPHONOBUTANE-1,2,4-TRICARBOXYLIC ACID | NALCO CHEMICAL COMPANY (US) | 1979-07-03 | — | — | US | disclosed |