Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL8884366 | 1.00 | MAPT (0.39) | MAPTKDM4EALOX15SMN1; SMN2MAPK1 | |
| Trolamine SCHEMBL27412368 | 1.00 | MAPT (0.39) | MAPTKDM4EALOX15SMN1; SMN2MAPK1 | |
| Trolamine SCHEMBL5874691 | 1.00 | MAPT (0.39) | MAPTKDM4EALOX15SMN1; SMN2MAPK1 | |
| Trolamine SCHEMBL7796775 | 1.00 | MAPT (0.39) | MAPTKDM4EALOX15SMN1; SMN2MAPK1 | |
| Trolamine SCHEMBL22288216 | 0.97 | MAPT (0.37) | MAPTKDM4EALOX15SMN1; SMN2MAPK1 | |
| Trolamine SCHEMBL7564590 | 0.97 | MAPT (0.37) | MAPTKDM4EALOX15SMN1; SMN2MAPK1 | |
| Trolamine SCHEMBL28289278 | 0.94 | MAPT (0.41) | MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL28297813 | 0.91 | MAPT (0.39) | MAPTKDM4EALOX15SMN1; SMN2MAPK1 | |
| Trolamine SCHEMBL5084486 | 0.89 | KDM4E (0.38) | MAPTKDM4EALOX15SMN1; SMN2 | |
| Trolamine SCHEMBL11775360 | 0.88 | MAPT (0.36) | MAPTKDM4EALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 860 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528050-B2 | Biocide composition and method | JUSTEQ, LLC (US) | 2026-01-20 | — | — | US | claimed |
| US-20260009493-A1 | VENTURI-BASED FLOW SYSTEM FOR SCALE INHIBITION | SAUDI ARABIAN OIL CO (SA) | 2026-01-08 | — | — | US | claimed |
| CN-120059492-A | Modified basalt flake, corrosion-resistant coating and preparation method thereof | 珠海格力电器股份有限公司 | 2025-05-30 | — | — | CN | claimed |
| CN-119999681-A | Disinfectant with long-acting disinfection effect and preparation method thereof | 山东安捷高科消毒科技有限公司 | 2025-05-16 | — | — | CN | claimed |
| CN-117065786-B | Fe-Cu composite heteroatom molecular sieve catalyst, preparation method and application thereof | 太原理工大学 | 2025-05-02 | — | — | CN | claimed |
| CN-119823651-A | Insect pest prevention water-based asphalt paint for container underframe and processing technology thereof | 安徽欣苗新材料科技有限公司 | 2025-04-15 | — | — | CN | claimed |
| CN-119799402-A | Rust-proof volatile punching shear oil and preparation method thereof | 湖南鸿福实业有限公司 | 2025-04-11 | — | — | CN | claimed |
| US-20250114744-A1 | BIOCIDE COMPOSITION AND METHOD | ACCULAB CO., LTD. (KR) | 2025-04-10 | — | — | US | claimed |
| CN-119638230-A | Efficient grinding preparation process for steel slag-slag | 中建西部建设第九有限公司 | 2025-03-18 | — | — | CN | claimed |
| CN-119451386-A | Hole transport layer, perovskite solar cell and preparation method | 天合光能股份有限公司 | 2025-02-14 | — | — | CN | claimed |
| US-5712232-A | ANIONIC SURFACTANT AND A SALT | KAO CORPORATION (JP) | 1998-01-27 | — | — | US | claimed |
| US-5106872-A | Synergistic; insecticide/miticide and photosensitizer | CIBA-GEIGY CORPORATION (US) | 1992-04-21 | — | — | US | claimed |
| US-5008036-A | Colloidal sols of antimony pentoxide in an aqueous medium and their preparation | LAUREL INDUSTRIES, INC. (US) | 1991-04-16 | — | — | US | claimed |
| US-4804496-A | SPRAY DRYING ANTIMONY SOLS | PHILLIPS PETROLEUM COMPANY (US) | 1989-02-14 | — | — | US | claimed |
| EP-0282747-A2 | Rapidly dispersible compositions of antimony pentoxide | PHILLIPS PETROLEUM COMPANY (US) | 1988-09-21 | — | — | EP | claimed |
| US-RE31801-E | SUSTAINED RELEASE OF PLANT FOOD | HAWKEYE CHEMICAL COMPANY (US) | 1985-01-15 | — | — | US | claimed |
| US-4348301-A | OXIDATION OF ANTIMONY OR LOWER OXIDE THEREOF WITH HYDROGEN PEROXIDE | PPG INDUSTRIES, INC. (US) | 1982-09-07 | — | — | US | claimed |
| US-4313837-A | Using molybdates to inhibit corrosion in water-based metalworking fluids | AMAX, INC. (US) | 1982-02-02 | — | — | US | claimed |
| US-4244727-A | PREPARED BY THE PARTIAL CONDENSATION OF UREA AND FORMALDEHYDE IN THE PRESENCE OF AN ALKALI METAL HYDROXIDE | ASHLAND OIL, INC. (US) | 1981-01-13 | — | — | US | claimed |
| US-4223948-A | Process for the reduction of competitive oxidant consuming reactions in the solution mining of a mineral | ATLANTIC RICHFIELD COMPANY (US) | 1980-09-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12528050-B2 | Biocide composition and method | SLC6A12, SLC6A6, CLIC1 | MAPT 1653/4885KDM4E 3381/4885ALOX15 4279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.