Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828273 | 0.81 | ALDH1A1 (0.67) | ALDH1A1HPGDSMN1; SMN2TSHRNPC1 | |
| SCHEMBL2828269 | 0.81 | ALDH1A1 (0.67) | ALDH1A1HPGDSMN1; SMN2TSHRNPC1 | |
| SCHEMBL9644637 | 0.80 | ALDH1A1 (0.50) | ALDH1A1HPGDSMN1; SMN2TSHRNPC1 | |
| SCHEMBL28813918 | 0.80 | ALDH1A1 (0.59) | ALDH1A1HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL28977512 | 0.79 | ALDH1A1 (0.64) | ALDH1A1HPGDSMN1; SMN2TSHRNPC1 | |
| SCHEMBL3718010 | 0.79 | ATM (0.60) | ALDH1A1HPGDTSHRNPC1RAB9A | |
| SCHEMBL7790183 | 0.79 | EGFR (0.46) | NPC1RAB9ALMNASIGMAR1 | |
| SCHEMBL2998029 | 0.78 | TSHR (0.65) | ALDH1A1HPGDSMN1; SMN2TSHRNPC1 | |
| SCHEMBL4582840 | 0.78 | PTPN1 (0.63) | ALDH1A1HPGDSMN1; SMN2TSHRMEN1 | |
| SCHEMBL296300 | 0.76 | TSHR (0.61) | ALDH1A1HPGDSMN1; SMN2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159260-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000055124-A2 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |