SCHEMBL7797121

SCHEMBL7797121

COc1cc(-c2nc(-c3ccc(N(C)C)cc3)c[nH]2)ccc1O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDGFRB P09619 3/20 0.51
KIT P10721 2/20 0.51
KDR P35968 2/20 0.51
FYN P06241 2/20 0.48
CXCL12 P48061 2/20 0.47
JAK2 O60674 1/20 0.47
FLT3 P36888 1/20 0.47
GAA P10253 2/20 0.46
RECQL P46063 1/20 0.46
GFER P55789 1/20 0.46
NOX1 Q9Y5S8 2/20 0.44
ALOX5 P09917 1/20 0.44
ALOX12 P18054 1/20 0.44
NFKB1 P19838 1/20 0.44
STAT3 P40763 1/20 0.44
NFKB2 Q00653 1/20 0.44
RELA Q04206 1/20 0.44
APP P05067 2/20 0.43
POLB P06746 1/20 0.43
CYP1A1 P04798 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7773262 0.89 SMPD3 (0.45) PDGFRBKITKDRNOX1APP
SCHEMBL12112575 0.81 PDGFRB (0.54) PDGFRBKITKDRFYNCXCL12
SCHEMBL11614979 0.78 APP (0.50) PDGFRBKITKDRNOX1NFKB1
SCHEMBL12112482 0.78 PDGFRB (0.51) PDGFRBKITKDRFYNCXCL12
SCHEMBL5676205 0.77 NOX1 (0.76) NOX1ALOX5CYP1A1CYP1A2CYP1B1
SCHEMBL9425243 0.77 NOX1 (0.58) JAK2FLT3GAARECQLGFER
SCHEMBL26093677 0.76 KDM4E (0.55) PDGFRBKITGAAGFERALOX5
SCHEMBL30387478 0.76 KDM4E (0.55) PDGFRBKITGAAGFERALOX5
Hydrochloric Acid SCHEMBL9426019 0.76 NOX1 (0.57) JAK2FLT3GAARECQLGFER
SCHEMBL10353519 0.74 ERN1 (0.43) PDGFRBKITKDRGAAALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4089747-A OXIDATION OF DYE-PROVIDING MATERIALS, A SULFONYL HYDRAZONE AND A COUPLER OR A TRIARYLIMIDAZOLE EASTMAN KODAK COMPANY (US) 1978-05-16 US claimed
CN-1100884-C Homogenous method for assay of double-stranded nucleic acids using fluorescent dyes and kit useful therein CLINICAL DIAGNOSTIC SYST (US) 2003-02-05 CN disclosed
EP-0726312-B1 Methods for capture and selective release of nucleic acids JOHNSON & JOHNSON CLIN DIAG (US) 2001-12-12 EP disclosed
CN-1114359-A Homogenous method for assay of double-stranded nucleic acids using fluorescent dyes and kit useful therein CLINICAL DIAGNOSTIC SYST (US) 1996-01-03 CN disclosed
EP-0687910-A1 Test kit and method for competitive specific binding assay Johnson & Johnson Clinical Diagnostics, Inc. (US) 1995-12-20 EP disclosed