SCHEMBL9425243

SCHEMBL9425243

COc1cc(-c2nc(-c3ccc(N(C)C)cc3)c(C)[nH]2)ccc1O

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NOX1 Q9Y5S8 4/20 0.58
SMPD3 Q9NY59 7/20 0.57
CYP1A1 P04798 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP1B1 Q16678 1/20 0.47
POLB P06746 1/20 0.45
PARP1 P09874 1/20 0.44
APP P05067 1/20 0.43
GAA P10253 1/20 0.42
RECQL P46063 1/20 0.42
GFER P55789 1/20 0.42
JAK2 O60674 1/20 0.41
FLT3 P36888 1/20 0.41
RIPK1 Q13546 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9426019 0.99 NOX1 (0.57) NOX1SMPD3CYP1A1CYP1A2CYP1B1
SCHEMBL9331183 0.89 SMPD3 (0.73) NOX1SMPD3GAA
SCHEMBL5676205 0.88 NOX1 (0.76) NOX1SMPD3CYP1A1CYP1A2CYP1B1
Hydrochloric Acid SCHEMBL1735170 0.88 SMPD3 (0.71) NOX1SMPD3GAA
SCHEMBL9426226 0.84 AMY1A (0.53) NOX1SMPD3POLBPARP1
SCHEMBL9425407 0.82 SMPD3 (0.48) NOX1SMPD3POLBPARP1
SCHEMBL9185758 0.81 AMY1A (0.51) NOX1SMPD3GAA
SCHEMBL9425781 0.81 SMPD3 (0.47) NOX1SMPD3PARP1
SCHEMBL9425807 0.81 SMPD3 (0.52) NOX1SMPD3PARP1
SCHEMBL9188234 0.80 SMPD3 (0.54) NOX1SMPD3GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5292669-A Chromogenic agent, oxidizer BOEHRINGER MANNHEIM GMBH (DE) 1994-03-08 US disclosed