SCHEMBL7797188

SCHEMBL7797188

O=C(O)c1c(O)c2c(O)cccc2oc1=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.48
CA9 Q16790 3/20 0.48
CA1 P00915 2/20 0.48
CA7 P43166 2/20 0.48
CA14 Q9ULX7 2/20 0.48
CA2 P00918 1/20 0.48
MEN1 O00255 4/20 0.47
CYP3A4 P08684 4/20 0.47
MAPT P10636 4/20 0.47
KMT2A Q03164 4/20 0.47
HPGD P15428 4/20 0.47
ALOX15 P16050 3/20 0.47
MAPK1 P28482 3/20 0.47
LMNA P02545 2/20 0.47
KDM4E B2RXH2 2/20 0.47
HSD17B10 Q99714 2/20 0.47
USP2 O75604 1/20 0.47
TP53 P04637 1/20 0.47
MAOA P21397 4/20 0.45
AR P10275 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28493571 0.81 ALDH1A1 (0.45) CA12CA9MAPTKMT2AHPGD
SCHEMBL27582279 0.81 CA12 (0.56) CA12CA9CA1CA7CA14
SCHEMBL31457155 0.80 MAOA (0.52) MEN1CYP3A4MAPTKMT2AHPGD
SCHEMBL471846 0.80 MAOA (0.52) MEN1CYP3A4MAPTKMT2AHPGD
SCHEMBL1648027 0.77 CA12 (0.73) CA12CA9MEN1CYP3A4MAPT
SCHEMBL29901650 0.77 CA12 (0.73) CA12CA9MEN1CYP3A4MAPT
SCHEMBL25370680 0.75 KDM4E (0.61) MEN1CYP3A4MAPTKMT2AHPGD
SCHEMBL11479865 0.75 CYP3A4 (0.58) CA12CA9CA1CA2MEN1
Sulfuric Acid SCHEMBL4659424 0.74 MAOA (0.46) MEN1CYP3A4MAPTKMT2AHPGD
SCHEMBL6204087 0.74 CA12 (0.50) CA12CA9CA1CA7CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0900230-B1 ESCULETIN DERIVATIVES IDG UK LTD (GB) 2001-12-12 EP disclosed
US-6287798-B1 COMPOUND WHICH IS HYDROLYZABLE BY MICROORGANISMS FOR DETECTION IN SAMPLES; FORMS BLACK, INSOLUBLE, NONDIFFUSABLE COMPOUND IDG (UK) LIMITED (GB) 2001-09-11 US disclosed
US-6008008-A 6- OR 7-SUBSTITUTED DERIVATIVES WHICH ARE MICROBIALLY HYDROLYZABLE TO FLUORESCENT, IRON CHELATING MOIETIES WHICH ARE NONDIFFUSING IN AGAR AND OTHER AQUEOUS ENVIRONMENTS; FOR DETECTION OF MICROORGANISMS IDG (UK) LIMITED (GB) 1999-12-28 US disclosed
EP-0900230-A2 ESCULETIN DERIVATIVES IDG (UK) Limited (GB) 1999-03-10 EP disclosed
WO-1997041138-A2 ESCULETIN DERIVATIVES IDG (UK) LIMITED (GB) 1997-11-06 WO disclosed