Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
| ▸ | CFB | P00751 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6798137 | 0.98 | CHRNB2 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL28309573 | 0.95 | CHRNB2 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL11938966 | 0.95 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL4318786 | 0.90 | CHRNB2 (0.54) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL28516636 | 0.89 | DRD2 (0.47) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL18751632 | 0.87 | CHRNB2 (0.56) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL11938963 | 0.87 | CHRNA7 (0.47) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL11939423 | 0.85 | ACHE (0.42) | CYP3A4CYP2D6KCNH2DRD2DRD4 | |
| SCHEMBL11860669 | 0.84 | CHRNB2 (0.47) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL22473185 | 0.83 | CHRNB2 (0.53) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110035995-A | MAChR M4Positive allosteric modulators | 范德比尔特大学 | 2019-07-19 | — | — | CN | disclosed |
| CN-106478662-B | 5-HT3 receptor antagonist | 武田药品工业株式会社 | 2019-07-02 | — | — | CN | disclosed |
| CN-109890388-A | MAChR M4Positive allosteric modulators | 范德比尔特大学 | 2019-06-14 | — | — | CN | disclosed |
| CN-109863139-A | Muscarinic acetylcholine receptor M4Positive allosteric modulators of | 范德比尔特大学 | 2019-06-07 | — | — | CN | disclosed |
| CN-109862893-A | Muscarinic acetylcholine receptor M4Positive allosteric modulators of | 范德比尔特大学 | 2019-06-07 | — | — | CN | disclosed |
| CN-109310668-A | Positive allosteric modulators of muscarinic acetylcholine receptor M4 | 范德比尔特大学 | 2019-02-05 | — | — | CN | disclosed |
| CN-108779098-A | Therapeutic compound | 希四克斯探索有限公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-108602760-A | Indane derivatives as MG L UR7 modulators | 武田药品工业株式会社 | 2018-09-28 | — | — | CN | disclosed |
| CN-105263922-B | Triazole compounds and their use as gamma secretase modulators | 阿克图拉姆生命科学股份公司 | 2018-08-17 | — | — | CN | disclosed |
| CN-105324372-B | 1-sulfonylpiperidine derivatives as prokineticin receptor modulators | 武田药品工业株式会社 | 2018-03-06 | — | — | CN | disclosed |
| CN-101501024-A | Muscarinic receptor agonists that are effective in the treatment of pain, alzheimer's disease and schizophrenia | ASTRAZENECA AB (SE) | 2009-08-05 | — | — | CN | disclosed |
| CN-101501025-A | Muscarinic receptor agonists that are effective in the treatment of pain, alzheimer's disease and schizophrenia | ASTRAZENECA AB (SE) | 2009-08-05 | — | — | CN | disclosed |
| CN-101490056-A | Nicotinic acetylcholine receptor ligands 101 | ASTRAZENECA AB (SE) | 2009-07-22 | — | — | CN | disclosed |
| CN-101472917-A | Benzimidazole 5-sulfonamide derivatives as cannabinoid 1 (CB1) receptor ligands | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | CN | disclosed |
| CN-101421237-A | Metabotropic glutamate receptor-potentiating soindolones | ASTRAZENECA AB (SE) | 2009-04-29 | — | — | CN | disclosed |
| CN-101410392-A | Amide-substituted quinolines | ASTRAZENECA AB (SE) | 2009-04-15 | — | — | CN | disclosed |
| CN-101400677-A | Compounds | ASTRAZENECA AB (SE) | 2009-04-01 | — | — | CN | disclosed |
| CN-101379042-A | Substituted cinnoline derivatives as GABAA receptor modulators and methods of synthesis thereof | ASTRAZENECA AB (SE) | 2009-03-04 | — | — | CN | disclosed |
| CN-101356167-A | Chroman compounds as 5-HT1B antagon | ASTRAZENECA AB (SE) | 2009-01-28 | — | — | CN | disclosed |
| US-20010047097-A1 | Process for the preparation of arylethylamines by amination of arylolefins | AVENTIS RESEARCH & TECHNOLOGIES GMBH & CO KG (DE) | 2001-11-29 | — | — | US | disclosed |