Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7797390 | 0.81 | PDE5A (0.48) | PDE5AALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL27364625 | 0.81 | MPO (0.53) | PDE5AALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL27382271 | 0.80 | PDE5A (0.49) | PDE5AALDH1A1KMT2AMEN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27376209 | 0.79 | PDE5A (0.48) | PDE5AALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7796286 | 0.78 | PDE4A (0.64) | PDE5AALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL27355411 | 0.73 | KMT2A (0.45) | PDE5AALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL27379775 | 0.73 | PDE5A (0.49) | PDE5AALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL27357112 | 0.73 | HSP90AB1 (0.54) | PDE5AALDH1A1KMT2AMEN1HSP90AB1 | |
| SCHEMBL7493587 | 0.73 | PDE5A (0.69) | PDE5AALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5805232 | 0.73 | TRAP1 (0.53) | ALDH1A1HSP90AB1HSD17B10TRAP1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010031760-A1 | Method of treating a patient having precancerous lesions with quinazoline derivatives | PAMUKCU RIFAT (US) | 2001-10-18 | — | — | US | disclosed |
| US-6046206-A | Method of treating a patient having a precancerous lesions with amide quinazoline derivatives | CELL PATHWAYS, INC. (US) | 2000-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010031760-A1 | Method of treating a patient having precancerous lesions with quinazoline derivatives | MKI67, PCNA, NQO2 | PDE5A 2260/4885ALDH1A1 565/4885KMT2A 1203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.