SCHEMBL7797528

SCHEMBL7797528

COc1ccccc1C(=O)NS(=O)(=O)c1ccc(N)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.59
MEN1 O00255 1/20 0.58
LMNA P02545 1/20 0.58
KMT2A Q03164 1/20 0.58
FLT1 P17948 3/20 0.56
FLT4 P35916 3/20 0.56
KDR P35968 3/20 0.56
CTSD P07339 1/20 0.55
POLB P06746 1/20 0.53
DHFR P00374 1/20 0.53
TSHR P16473 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
KAT6A Q92794 1/20 0.52
RXFP1 Q9HBX9 1/20 0.52
THRB P10828 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
ALDH1A1 P00352 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9414560 0.89 POLB (0.68) GAAMEN1KMT2AFLT1FLT4
SCHEMBL16244081 0.88 KDM4E (0.62) GAAFLT1FLT4KDRCTSD
SCHEMBL18803129 0.86 POLB (0.64) GAALMNAFLT1FLT4KDR
SCHEMBL16634981 0.85 GAA (0.57) GAALMNAKMT2AFLT1FLT4
SCHEMBL15495162 0.84 RXFP1 (0.60) GAAMEN1KMT2AFLT1FLT4
Formamide SCHEMBL28301130 0.84 FLT1 (0.52) GAAFLT1FLT4KDRCTSD
SCHEMBL26161946 0.84 GAA (0.56) GAALMNAKMT2AFLT1FLT4
SCHEMBL28129967 0.84 GAA (0.60) GAAFLT1FLT4KDRCTSD
SCHEMBL3302654 0.84 FLT1 (0.57) GAALMNAFLT1FLT4KDR
SCHEMBL27650215 0.83 GAA (0.55) GAAFLT1FLT4KDRCTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912089-B1 NOVEL N-ACYL SULPHONAMIDES, NOVEL MIXTURES OF HERBICIDES AND ANTIDOTES AND THEIR USE AVENTIS CROPSCIENCE GMBH (DE) 2001-11-28 EP disclosed
US-6235680-B1 REDUCING SIDE EFFECT OF PESTICIDE HOECHST SCHERING AGREVO GMBH (DE) 2001-05-22 US disclosed
EP-0912089-A1 NOVEL N-ACYL SULPHONAMIDES, NOVEL MIXTURES OF HERBICIDES AND ANTIDOTES AND THEIR USE Hoechst Schering AgrEvo GmbH (DE) 1999-05-06 EP disclosed
WO-1997045016-A1 NOVEL N-ACYL SULPHONAMIDES, NOVEL MIXTURES OF HERBICIDES AND ANTIDOTES AND THEIR USE HOECHST SCHERING AGREVO GMBH (DE) 1997-12-04 WO disclosed