SCHEMBL16634981

SCHEMBL16634981

COc1ccccc1C(=O)NS(=O)(=O)c1ccc(C(=O)O)cc1

nearest known ligand 0.57

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.57
FLT1 P17948 1/20 0.55
FLT4 P35916 1/20 0.55
KDR P35968 1/20 0.55
RAB9A P51151 4/20 0.54
NPC1 O15118 1/20 0.54
POLB P06746 2/20 0.52
KDM4E B2RXH2 2/20 0.51
ALDH1A1 P00352 1/20 0.51
MAPT P10636 1/20 0.51
KAT6A Q92794 2/20 0.51
RXFP1 Q9HBX9 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.50
HPGD P15428 1/20 0.50
CTSD P07339 1/20 0.50
THRB P10828 1/20 0.49
LMNA P02545 2/20 0.49
KMT2A Q03164 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16244081 0.90 KDM4E (0.62) GAAFLT1FLT4KDRRAB9A
SCHEMBL18803129 0.88 POLB (0.64) GAAFLT1FLT4KDRRAB9A
SCHEMBL3302654 0.88 FLT1 (0.57) GAAFLT1FLT4KDRRAB9A
SCHEMBL26161946 0.88 GAA (0.56) GAAFLT1FLT4KDRRAB9A
SCHEMBL9414560 0.87 POLB (0.68) GAAFLT1FLT4KDRRAB9A
SCHEMBL125423 0.86 L3MBTL1 (0.54) GAAFLT1FLT4KDRRAB9A
SCHEMBL13754035 0.86 GAA (0.54) GAAFLT1FLT4KDRRAB9A
SCHEMBL7797528 0.85 GAA (0.59) GAAFLT1FLT4KDRPOLB
SCHEMBL3303687 0.83 OPRM1 (0.53) GAAFLT1FLT4KDRRAB9A
SCHEMBL120129 0.83 KCNA3 (0.52) GAAFLT1FLT4KDRRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116606230-A Preparation method of acyl sulfamoyl benzamide 拜耳作物科学股份公司 2023-08-18 CN disclosed
US-10421713-B2 Process for preparing 4[[(benzoyl)amino]sulphonyl]benzoyl chlorides and preparation of acylsulphamoylbenzamides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-09-24 US disclosed
EP-3280699-B1 METHOD FOR PREPARING ACYLSULFAMOYLBENZAMIDES BAYER CROPSCIENCE AG (DE) 2019-07-10 EP disclosed
EP-3280699-A1 METHOD FOR PRODUCING ACYLSULFAMOYLBENZAMIDES Bayer CropScience Aktiengesellschaft (DE) 2018-02-14 EP disclosed
US-20170305845-A1 PROCESS FOR PREPARING 4[[(BENZOYL)AMINO]SULPHONYL]BENZOYL CHLORIDES AND PREPARATION OF ACYLSULPHAMOYLBENZAMIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-10-26 US disclosed
EP-3055292-B1 PROCESS FOR PREPARING 4-[[(BENZOYL)AMINO]SULPHONYL]BENZOYL CHLORIDES AND PREPARATION OF ACYLSULPHAMOYLBENZAMIDES BAYER CROPSCIENCE AG (DE) 2017-08-16 EP disclosed
US-9725409-B2 Process for preparing 4[[(benzoyl)amino]sulphonyl]benzoyl chlorides and preparation of acylsulphamoylbenzamides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-08-08 US disclosed
WO-2016162299-A1 METHOD FOR PRODUCING ACYLSULFAMOYLBENZAMIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-10-13 WO disclosed
EP-3055292-A1 PROCESS FOR PREPARING 4-[[(BENZOYL)AMINO]SULPHONYL]BENZOYL CHLORIDES AND PREPARATION OF ACYLSULPHAMOYLBENZAMIDES Bayer CropScience Aktiengesellschaft (DE) 2016-08-17 EP disclosed
US-20160214929-A1 PROCESS FOR PREPARING 4[[(BENZOYL)AMINO]SULPHONYL]BENZOYL CHLORIDES AND PREPARATION OF ACYLSULPHAMOYLBENZAMIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-07-28 US disclosed
WO-2015052156-A1 PROCESS FOR PREPARING 4-[[(BENZOYL)AMINO]SULPHONYL]BENZOYL CHLORIDES AND PREPARATION OF ACYLSULPHAMOYLBENZAMIDES BAYER CROPSCIENCE AG (DE) 2015-04-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10421713-B2 Process for preparing 4[[(benzoyl)amino]sulphonyl]benzoyl chlorides and preparation of acylsulphamoylbenzamides SPTSSB, ACSL3, ASNS GAA 325/4885FLT1 4548/4885FLT4 4032/4885
US-20160214929-A1 PROCESS FOR PREPARING 4[[(BENZOYL)AMINO]SULPHONYL]BENZOYL CHLORIDES AND PREPARATION OF ACYLSULPHAMOYLBENZAMIDES SPTSSB, STS, ACSL4 GAA 915/4885FLT1 4564/4885FLT4 3892/4885
US-20170305845-A1 PROCESS FOR PREPARING 4[[(BENZOYL)AMINO]SULPHONYL]BENZOYL CHLORIDES AND PREPARATION OF ACYLSULPHAMOYLBENZAMIDES SPTSSB, STS, ACSL3 GAA 664/4885FLT1 4546/4885FLT4 3796/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.