Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16431087 | 0.85 | HDAC3 (0.53) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL30852311 | 0.85 | HDAC3 (0.53) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL5415859 | 0.83 | GAA (0.44) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL30484132 | 0.83 | ALDH1A1 (0.58) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL1207100 | 0.83 | ALDH1A1 (0.58) | MAPTGAAALDH1A1HSD17B10CFTR | |
| Kynuramine SCHEMBL2801613 | 0.82 | MAPT (0.50) | MAPTGAAALDH1A1HSD17B10CFTR | |
| Kynuramine SCHEMBL30555814 | 0.82 | MAPT (0.50) | MAPTGAAALDH1A1HSD17B10CFTR | |
| Hydrochloric Acid SCHEMBL7799850 | 0.81 | GAA (0.43) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL312279 | 0.81 | ALDH1A1 (0.58) | MAPTALDH1A1HSD17B10CFTRKDM4E | |
| SCHEMBL28685165 | 0.80 | ALDH1A1 (0.60) | MAPTALDH1A1HSD17B10KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1100755-C | Aminophenyl ketone derivative and preparation method thereof | AMERICAN CYANIAMID CO (US) | 2003-02-05 | — | — | CN | disclosed |
| EP-0849262-B1 | Aminophenyl ketone derivatives and a method for the preparation thereof | AMERICAN CYANAMID CO (US) | 2001-10-17 | — | — | EP | disclosed |
| CN-1073086-C | Process for the manufacture of cycloalkyl and haloalkyl O-aminophenyl ketones | AMERICAN CYANAMID CO (US) | 2001-10-17 | — | — | CN | disclosed |
| US-6127576-A | Aminophenyl ketone derivatives and a method for the preparation thereof | AMERICAN CYANAMID COMPANY (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0849262-A1 | Aminophenyl ketone derivatives and a method for the preparation thereof | American Cyanamid Company (US) | 1998-06-24 | — | — | EP | disclosed |
| CN-1185430-A | Aminophenyl ketone derivative and preparation method thereof | AMERICAN CYANIAMID CO (US) | 1998-06-24 | — | — | CN | disclosed |
| EP-0655436-B1 | Improved process for the manufacture of cycloalkyl and haloalkyl o-aminophenyl ketones | AMERICAN CYANAMID CO (US) | 1998-03-11 | — | — | EP | disclosed |
| CN-1122327-A | Process for the manufacture of cycloalkyl and haloalkyl O-aminophenyl ketones | AMERICAN CYANAMID CO (US) | 1996-05-15 | — | — | CN | disclosed |
| EP-0655436-A1 | Improved process for the manufacture of cycloalkyl and haloalkyl o-aminophenyl ketones | AMERICAN CYANAMID COMPANY (US) | 1995-05-31 | — | — | EP | disclosed |
| US-5362911-A | Process for the preparation of o-aminophenyl cyclo-propyl ketone | AMERICAN CYANAMID COMPANY (US) | 1994-11-08 | — | — | US | disclosed |