Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30484132 | 1.00 | ALDH1A1 (0.58) | ALDH1A1HSD17B10KDM4EPOLBGABRA1 | |
| SCHEMBL312279 | 0.95 | ALDH1A1 (0.58) | ALDH1A1HSD17B10KDM4EPOLBCFTR | |
| SCHEMBL28685165 | 0.93 | ALDH1A1 (0.60) | ALDH1A1HSD17B10KDM4EPOLBHSD17B3 | |
| SCHEMBL27397628 | 0.93 | ALDH1A1 (0.60) | ALDH1A1HSD17B10KDM4EPOLBHSD17B3 | |
| SCHEMBL27591991 | 0.93 | ALDH1A1 (0.60) | ALDH1A1HSD17B10KDM4EPOLBHSD17B3 | |
| Water SCHEMBL27519090 | 0.91 | ALDH1A1 (0.59) | ALDH1A1HSD17B10KDM4EPOLBHSD17B3 | |
| SCHEMBL4230481 | 0.89 | ALDH1A1 (0.55) | ALDH1A1HSD17B10KDM4EPOLBCFTR | |
| SCHEMBL30125359 | 0.86 | GABRA1 (0.54) | ALDH1A1KDM4EGABRA1GABRB2HSD17B3 | |
| SCHEMBL83892 | 0.86 | GABRA1 (0.54) | ALDH1A1KDM4EGABRA1GABRB2HSD17B3 | |
| SCHEMBL9630981 | 0.86 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4EPOLBGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116377458-A | Method for electrochemically synthesizing quinazoline derivative | 安徽科技学院 | 2023-07-04 | — | — | CN | claimed |
| CN-116377458-A | Method for electrochemically synthesizing quinazoline derivative | 安徽科技学院 | 2023-07-04 | — | — | CN | disclosed |
| EP-1751118-B1 | PYRIMIDINES FOR USE AS PLK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2014-12-03 | — | — | EP | disclosed |
| US-20110039847-A1 | AMIDE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC (US) | 2011-02-17 | — | — | US | disclosed |
| US-20110039847-A1 | AMIDE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC (US) | 2011-02-17 | — | — | US | disclosed |
| US-20110039847-A1 | AMIDE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC (US) | 2011-02-17 | — | — | US | disclosed |
| US-7750151-B2 | Inhibitors of Akt activity | MERCK SHARP & DOHME CORP. (US) | 2010-07-06 | — | — | US | disclosed |
| WO-2009058348-A1 | AMIDE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-07 | — | — | WO | disclosed |
| US-20080280899-A1 | Inhibitors of Akt Activity | MERCK SHARP & DOHME CORP. | 2008-11-13 | — | — | US | disclosed |
| US-7408025-B2 | Lipopeptides as antibacterial agents | CUBIST PHARMACEUTICALS, INC. (US) | 2008-08-05 | — | — | US | disclosed |
| CN-100384821-C | Cetp activity inhibitors | JAPAN TOBACCO INC (JP) | 2008-04-30 | — | — | CN | disclosed |
| CN-1893943-A | Pyrazolopyridines and analogs thereof | 3M INNOVATIVE PROPERTIES CO (US) | 2007-01-10 | — | — | CN | disclosed |
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| CN-1252053-A | Cetp activity inhibitors | JAPAN TOBACCO INC (JP) | 2000-05-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280899-A1 | Inhibitors of Akt Activity | AKT1, AKT2, AKT3 | ALDH1A1 3486/4885HSD17B10 2295/4885KDM4E 1498/4885 |
| US-20110039847-A1 | AMIDE DERIVATIVES AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | ALDH1A1 871/4885HSD17B10 769/4885KDM4E 1780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.