Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.89 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.89 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.89 |
| ▸ | LMNA | P02545 | 3/20 | 0.89 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.89 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.89 |
| ▸ | THPO | P40225 | 2/20 | 0.89 |
| ▸ | MAPT | P10636 | 2/20 | 0.89 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.89 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.89 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.89 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.89 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.89 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.89 |
| ▸ | ACHE | P22303 | 1/20 | 0.89 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.89 |
| ▸ | DRD3 | P35462 | 1/20 | 0.89 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Melphalan SCHEMBL5325132 | 0.94 | HIF1A (1.00) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA | |
| (R)-Melphalan SCHEMBL5873 | 0.94 | HIF1A (1.00) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA | |
| Melphalan SCHEMBL563239 | 0.94 | HIF1A (1.00) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA | |
| Sarcolysin SCHEMBL414671 | 0.94 | HIF1A (1.00) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA | |
| Melphalan SCHEMBL5872 | 0.94 | HIF1A (1.00) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA | |
| Melphalan SCHEMBL11029192 | 0.93 | HIF1A (0.97) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA | |
| Sarcolysin SCHEMBL2680958 | 0.93 | HIF1A (0.97) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA | |
| Melphalan SCHEMBL2723742 | 0.93 | HIF1A (0.97) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA | |
| Sarcolysin SCHEMBL28782154 | 0.93 | HIF1A (0.97) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA | |
| Melphalan SCHEMBL4150935 | 0.93 | HIF1A (0.97) | HIF1ACYP3A4ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765720-B2 | Combination therapy for the treatment of multiple myeloma | CEPHALON, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| WO-2010138141-A1 | COMBINATION THERAPY FOR THE TREATMENT OF MULTIPLE MYELOMA | CEPHALON, INC. (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138101-A1 | COMBINATION THERAPY FOR THE TREATMENT OF MULTIPLE MYELOMA USING CEP-18770 TOGETHER WITH BORTEZOMIB OR MEPHALAN | CEPHALON, INC. (US) | 2010-12-02 | — | — | WO | disclosed |