Cyclohexylamine

Cyclohexylamine

SCHEMBL7797971

Cc1ccc(C=O)cc1.NC1CCCCC1

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.59
TRPM8 Q7Z2W7 2/20 0.50
NPC1 O15118 4/20 0.41
RAB9A P51151 4/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
MAPT P10636 1/20 0.41
KMT2A Q03164 1/20 0.41
ALDH1A1 P00352 3/20 0.39
KDM4E B2RXH2 2/20 0.39
CYP1A2 P05177 2/20 0.38
HPGD P15428 1/20 0.38
CYP2C19 P33261 1/20 0.38
CYP3A4 P08684 1/20 0.38
TSHR P16473 1/20 0.38
POLB P06746 1/20 0.37
ALDH1A3 P47895 1/20 0.37
TRIM24 O15164 1/20 0.36
TRIM33 Q9UPN9 1/20 0.36
EPHX1 P07099 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cyclohexylamine SCHEMBL7792798 0.81 CYP1A2 (0.43) NPC1RAB9ASMN1; SMN2KMT2AALDH1A1
Cyclohexylamine SCHEMBL7800230 0.81 ALDH1A1 (0.41) NPC1RAB9ASMN1; SMN2MAPTKMT2A
4-Hydroxybenzaldehyde SCHEMBL7798433 0.81 ALDH5A1 (0.59) NPC1RAB9ASMN1; SMN2MAPTKMT2A
Benzaldehyde SCHEMBL8035182 0.81 ALDH1A1 (0.56) CYP2A6TRPM8SMN1; SMN2MAPTALDH1A1
Cycloheptanamine SCHEMBL7792128 0.81 ALDH1A1 (0.56) CYP2A6TRPM8SMN1; SMN2MAPTALDH1A1
Cyclohexylamine SCHEMBL7802774 0.81 ALDH1A1 (0.63) CYP2A6TRPM8NPC1RAB9ASMN1; SMN2
Anisaldehyde SCHEMBL7800096 0.81 ALDH1A1 (0.63) CYP2A6TRPM8NPC1RAB9AKMT2A
Cyclohexylamine SCHEMBL7798634 0.81 CYP2A6 (0.63) CYP2A6TRPM8NPC1RAB9ASMN1; SMN2
Cuminaldehyde SCHEMBL7801634 0.81 TYR (0.63) NPC1RAB9ASMN1; SMN2MAPTALDH1A1
Cyclohexylamine SCHEMBL7798522 0.80 KMT2A (0.43) KMT2AALDH1A1CYP1A2EPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1076649-A1 ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME TREGA BIOSCIENCES, INC. (US) 2001-02-21 EP disclosed
US-6127381-A A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY LION BIOSCIENCE AG (DE) 2000-10-03 US disclosed
WO-1999055679-A1 ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME TREGA BIOSCIENCES, INC. (US) 1999-11-04 WO disclosed