Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7800110 | 0.89 | TAAR1 (0.60) | TAAR1HRH1TTRALDH1A1MEN1 | |
| SCHEMBL7792570 | 0.81 | NPC1 (0.59) | TAAR1TTRALDH1A1KDM4EMAOA | |
| SCHEMBL7802655 | 0.78 | MAOA (0.46) | TTRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL25809767 | 0.77 | HRH1 (0.58) | TAAR1HRH1ADRA1A | |
| SCHEMBL7798169 | 0.77 | NPC1 (0.63) | TTRALDH1A1KDM4EMAOAMAOB | |
| SCHEMBL2075852 | 0.77 | TTR (0.67) | TTRALDH1A1MEN1KMT2APOLB | |
| SCHEMBL2207553 | 0.77 | NPC1 (0.64) | ALDH1A1MEN1KMT2APOLBMAOA | |
| SCHEMBL98478 | 0.77 | MAOB (0.61) | TTRALDH1A1MEN1KMT2AMAOA | |
| SCHEMBL29484309 | 0.77 | MAOB (0.61) | TTRALDH1A1MEN1KMT2AMAOA | |
| SCHEMBL11482497 | 0.77 | MAOB (0.61) | TTRALDH1A1MEN1KMT2AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |