SCHEMBL2207553

SCHEMBL2207553

COc1ccccc1COc1cccc(C=O)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.64
RAB9A P51151 3/20 0.64
TDP1 Q9NUW8 1/20 0.62
MAOA P21397 7/20 0.60
MAOB P27338 7/20 0.60
ALDH1A1 P00352 5/20 0.60
SPHK2 Q9NRA0 1/20 0.56
SPHK1 Q9NYA1 1/20 0.56
MAPT P10636 2/20 0.53
HTT P42858 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
MEN1 O00255 1/20 0.53
POLB P06746 1/20 0.53
HPGD P15428 1/20 0.53
KMT2A Q03164 1/20 0.53
CCNB2 O95067 1/20 0.53
CDK1 P06493 1/20 0.53
CDK4 P11802 1/20 0.53
CCNB1 P14635 1/20 0.53
CCND1 P24385 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9036831 0.86 RAB9A (0.67) NPC1RAB9ATDP1MAOAMAOB
SCHEMBL15009057 0.84 ALDH1A1 (0.57) NPC1RAB9AALDH1A1SPHK2SPHK1
SCHEMBL12517230 0.82 CDK4 (0.75) NPC1RAB9ATDP1MAOAMAOB
SCHEMBL28668979 0.81 ALDH1A1 (0.78) NPC1RAB9AALDH1A1MAPTHTT
SCHEMBL4200604 0.79 NPC1 (0.68) NPC1RAB9ATDP1MAOAMAOB
SCHEMBL9303235 0.79 NPC1 (0.68) NPC1RAB9ATDP1MAOAMAOB
SCHEMBL8985589 0.79 NPC1 (0.68) NPC1RAB9ATDP1MAOAMAOB
SCHEMBL16399775 0.79 ALDH1A1 (0.50) NPC1RAB9ATDP1ALDH1A1SPHK2
SCHEMBL9034897 0.78 NPC1 (1.00) NPC1RAB9ATDP1MAOAMAOB
SCHEMBL4779293 0.78 ABCB1 (0.62) ALDH1A1MAPTHTTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12029708-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2024-07-09 US disclosed
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2023-07-13 US disclosed
US-11446261-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2022-09-20 US disclosed
CN-107151220-B Phenol compound containing benzyloxy phenyl, preparation method and application thereof 中国医学科学院药物研究所 2021-07-20 CN disclosed
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2021-03-18 US disclosed
US-10639286-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2020-05-05 US disclosed
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2019-06-20 US disclosed
US-10188615-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2019-01-29 US disclosed
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2018-06-28 US disclosed
EP-3210966-A1 ALKOXYPHENYLPROPYLAMINES FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION Acucela, Inc. (US) 2017-08-30 EP disclosed
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-08-23 US disclosed
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-24 US disclosed
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-17 US disclosed
US-7982071-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2011-07-19 US disclosed
US-20090326074-A1 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2009-12-31 US disclosed
EP-2091955-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT Acucela, Inc. (US) 2009-08-26 EP disclosed
WO-2009045479-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. (US) 2009-04-09 WO disclosed
US-5234946-A Anticholesterol, antilipemic BANYU PHARMACEUTICAL CO., LTD. (JP) 1993-08-10 US disclosed
EP-0318860-B1 SUBSTITUTED ALKYLAMINE DERIVATIVES BANYU PHARMACEUTICAL CO., LTD. (JP) 1993-06-16 EP disclosed
EP-0318860-A2 Substituted alkylamine derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 1989-06-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12029708-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER NPC1 47/4885RAB9A 2120/4885TDP1 499/4885
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER NPC1 47/4885RAB9A 2120/4885TDP1 499/4885
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER NPC1 47/4885RAB9A 2120/4885TDP1 499/4885
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER NPC1 47/4885RAB9A 2078/4885TDP1 529/4885
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER NPC1 47/4885RAB9A 2120/4885TDP1 499/4885
US-11446261-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER NPC1 47/4885RAB9A 2120/4885TDP1 499/4885
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER NPC1 47/4885RAB9A 2120/4885TDP1 499/4885
US-20090326074-A1 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER NPC1 47/4885RAB9A 2120/4885TDP1 499/4885
US-10188615-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER NPC1 47/4885RAB9A 2120/4885TDP1 499/4885
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER NPC1 47/4885RAB9A 2120/4885TDP1 499/4885
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER NPC1 47/4885RAB9A 2120/4885TDP1 499/4885
US-10639286-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER NPC1 47/4885RAB9A 2120/4885TDP1 499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.