SCHEMBL7798238

SCHEMBL7798238

CCCOc1ccc(C=O)cc1.COc1ccc(CN)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.57
LMNA P02545 3/20 0.57
SMN1; SMN2 Q16637 2/20 0.57
MAPT P10636 2/20 0.57
HPGD P15428 2/20 0.57
CYP2A6 P11509 1/20 0.54
MAOB P27338 2/20 0.53
HTT P42858 2/20 0.48
TSHR P16473 1/20 0.48
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
KEAP1 Q14145 1/20 0.45
NFE2L2 Q16236 1/20 0.45
TUBB4A P04350 1/20 0.45
TUBB P07437 1/20 0.45
TUBA3C P0DPH7 1/20 0.45
TUBA1B P68363 1/20 0.45
TUBA4A P68366 1/20 0.45
TUBB4B P68371 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7798023 0.89 TAAR1 (0.57) ALDH1A1LMNASMN1; SMN2MAPTHPGD
SCHEMBL7800381 0.88 MAOB (0.56) ALDH1A1LMNASMN1; SMN2MAPTHPGD
SCHEMBL541949 0.83 ALDH1A1 (0.68) ALDH1A1LMNASMN1; SMN2MAPTHPGD
SCHEMBL14134159 0.83 ALDH1A1 (0.68) ALDH1A1LMNASMN1; SMN2MAPTHPGD
SCHEMBL19214413 0.81 ALDH1A1 (0.76) ALDH1A1LMNASMN1; SMN2MAPTHPGD
SCHEMBL2911524 0.81 KEAP1 (0.63) ALDH1A1LMNASMN1; SMN2MAPTMAOB
Benzaldehyde SCHEMBL7792134 0.80 ALDH1A1 (0.58) ALDH1A1SMN1; SMN2CYP2A6MAOBHTT
SCHEMBL2231514 0.80 ALDH1A1 (0.63) ALDH1A1LMNASMN1; SMN2MAPTHPGD
SCHEMBL2232493 0.80 ALDH1A1 (0.63) ALDH1A1LMNASMN1; SMN2MAPTHPGD
SCHEMBL13687719 0.80 LMNA (0.58) LMNAMAPTMAOBHTTKEAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1076649-A1 ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME TREGA BIOSCIENCES, INC. (US) 2001-02-21 EP disclosed
US-6127381-A A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY LION BIOSCIENCE AG (DE) 2000-10-03 US disclosed
WO-1999055679-A1 ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME TREGA BIOSCIENCES, INC. (US) 1999-11-04 WO disclosed