SCHEMBL7798353

SCHEMBL7798353

NN1CCCCC1.O=Cc1ccc(Cl)cc1Cl

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.65
MAPT P10636 3/20 0.43
TSHR P16473 4/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
ALOX15 P16050 1/20 0.41
ERN1 O75460 1/20 0.40
ALDH1A1 P00352 5/20 0.39
KDM4E B2RXH2 2/20 0.39
GAA P10253 2/20 0.39
RAB9A P51151 1/20 0.39
HTT P42858 2/20 0.38
ALDH1A3 P47895 1/20 0.38
LMNA P02545 1/20 0.38
GPR55 Q9Y2T6 1/20 0.38
HPGD P15428 1/20 0.38
ATM Q13315 1/20 0.38
GRIN2D O15399 1/20 0.37
GRIN3B O60391 1/20 0.37
GRIN1 Q05586 1/20 0.37
GRIN2A Q12879 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29889164 0.80 TDP1 (1.00) TDP1MAPTL3MBTL1ERN1ALDH1A1
SCHEMBL95435 0.80 TDP1 (1.00) TDP1MAPTL3MBTL1ERN1ALDH1A1
Lysine SCHEMBL8025644 0.80 GSR (0.41) TDP1MAPTTSHRALDH1A1GAA
Ammonia Solution, Strong SCHEMBL8037724 0.78 TDP1 (0.95) TDP1MAPTL3MBTL1ERN1ALDH1A1
Cyclohexylamine SCHEMBL7798607 0.77 TDP1 (0.65) TDP1MAPTTSHRL3MBTL1ERN1
Cycloheptanamine SCHEMBL7801564 0.77 TDP1 (0.65) TDP1MAPTTSHRL3MBTL1ERN1
SCHEMBL8905673 0.74 TDP1 (0.53) TDP1MAPTTSHRL3MBTL1ALOX15
SCHEMBL23932966 0.73 ALDH1A1 (0.58) TDP1MAPTL3MBTL1ALOX15ALDH1A1
SCHEMBL19582589 0.73 ALDH1A1 (0.54) TDP1MAPTTSHRL3MBTL1ALOX15
SCHEMBL15093884 0.71 ALDH1A3 (0.53) TDP1MAPTTSHRL3MBTL1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1076649-A1 ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME TREGA BIOSCIENCES, INC. (US) 2001-02-21 EP disclosed
WO-1999055679-A1 ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME TREGA BIOSCIENCES, INC. (US) 1999-11-04 WO disclosed