Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 5/20 | 0.39 |
| ▸ | SLC1A5 | Q15758 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | EPOR | P19235 | 1/20 | 0.35 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7799061 | 1.00 | KMO (0.40) | KMOADAMTS5SLC1A5CYP3A4CYP2D6 | |
| 2-(Aminomethyl)Phenol SCHEMBL8035202 | 0.90 | KMO (0.44) | KMOADAMTS5SLC1A5CYP3A4CYP2D6 | |
| 2-(Aminomethyl)Phenol SCHEMBL8035206 | 0.90 | KMO (0.44) | KMOADAMTS5SLC1A5CYP3A4CYP2D6 | |
| Lysine SCHEMBL7802016 | 0.89 | SLC1A5 (0.46) | SLC1A5EPORGSRLTA4HEGLN2 | |
| Lysine SCHEMBL7802021 | 0.89 | SLC1A5 (0.46) | SLC1A5EPORGSRLTA4HEGLN2 | |
| Lysine SCHEMBL7802101 | 0.86 | LTA4H (0.42) | SLC1A5EPORGSRLTA4HEGLN2 | |
| Lysine SCHEMBL7802098 | 0.86 | LTA4H (0.42) | SLC1A5EPORGSRLTA4HEGLN2 | |
| 2-(Aminomethyl)Phenol SCHEMBL8041391 | 0.86 | KMO (0.47) | KMOADAMTS5CYP3A4CYP2D6CYP3A5 | |
| Lysine SCHEMBL8037512 | 0.82 | KMO (0.38) | KMOADAMTS5SLC5A1GSRFAAH | |
| Lysine SCHEMBL8037515 | 0.82 | KMO (0.38) | KMOADAMTS5SLC5A1GSRFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |